Hydrogen peroxide: A metabolic by-product or a common mediator of ageing signals?

被引：6

作者：

Giorgio M. ^{[1
]}

Trinei M. ^{[2
]}

Migliaccio E. ^{[1
]}

Pelicci P.G. ^{[1
]}

机构：

[1] Department of Experimental Oncology, IEO-European Institute of Oncology, IFOM-FIRC Institute of Molecular Oncology

[2] Congenia Srl

来源：

Nature Reviews Molecular Cell Biology | 2007年 / 8卷 / 9期

关键词：

D O I：

10.1038/nrm2240

中图分类号：

学科分类号：

摘要：

The reactive oxygen species that are generated by mitochondrial respiration, including hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of ageing. It is not clear, however, whether oxidative stress is the result of a genetic programme or the by-product of physiological processes. Recent findings demonstrate that a fraction of mitochondrial H2O2, produced by a specialized enzyme as a signalling molecule in the pathway of apoptosis, induces intracellular oxidative stress and accelerates ageing. We propose that genes that control H2O2 production are selected determinants of lifespan. © 2007 Nature Publishing Group.

引用

页码：722 / 728

页数：6

共 80 条

[71]

Nisoli E., Et al., Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS, Science, 310, pp. 314-317, (2005)

[72]

Weindruch R., Walford R.L., The Retardation of Ageing and Disease by Dietary Restriction, (1988)

[73]

Masaro E.J., Yu B.P., Bertrand H.A., Action of food restriction in delaying the ageing process, Proc. Natl Acad. Sci. USA, 79, pp. 4239-4241, (1982)

[74]

McCarter R.J., Palmer J., Energy metabolism and ageing: A lifelong study of Fischer 344 rats, Am. J. Physiol, 263, (1992)

[75]

Gredilla R., Lopez-Torres M., Barja G., Effect of time of restriction on the decrease in mitochondrial H<sub>2</sub>O<sub>2</sub> production and oxidative DNA damage in the heart of food-restricted rats, Microsc. Res. Tech, 59, pp. 273-277, (2002)

[76]

Hagopian K., Et al., Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria, Am. J. Physiol. Endocrinol. Metab, 288, (2005)

[77]

Agarwal S., Sharma S., Agrawal V., Roy N., Caloric restriction augments ROS defence in S. cerevisiae, by a Sir2p independent mechanism, Free Radic. Res, 39, pp. 55-62, (2005)

[78]

Lin S.J., Et al., Calorie restriction extends Saccharomyces cerevisiae life span by increasing respiration, Nature, 418, pp. 344-348, (2002)

[79]

Halliwell B., Gutteridge J.M.C., Free Radicals in Biology and Medicine, (1998)

[80]

Sohal R.S., Allen R.G., Oxidative stress as a causal factor in differentiation and ageing: A unifying hypothesis, Exp. Gerontol, 25, pp. 499-522, (1990)

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