Regulation of Leptin Production

被引：79

作者：

Considine R.V. ^{[1
]}

机构：

[1] Department of Medicine, Div. of Endocrinology and Metabolism, Indiana Univ. School of Medicine, Indianapolis, IN

来源：

Reviews in Endocrine and Metabolic Disorders | 2001年 / 2卷 / 4期

基金：

美国国家卫生研究院;

关键词：

Adipose tissue; Lep gene; Leptin; Transcription;

D O I：

10.1023/A:1011896331159

中图分类号：

学科分类号：

摘要：

Fat mass is the primary determinant of serum leptin in humans with energy intake and gender also having significant effects. Gender influences leptin production through the reproductive hormones. Glucose metabolism links food intake to leptin production and hexosamine biosynthesis appears to play a significant role in this process. Catecholamines inhibit leptin production and the sympathetic nervous system has been proposed to be the efferent arm of the leptin signal transduction pathway between adipose tissue and the central nervous system. Additional regulators of leptin production include glucocorticoids, cytokines and agonists of PPARγ. In addition to adipose tissue, leptin is produced in several other places including placenta, bone marrow, stomach, muscle and perhaps brain, thus increasing the number of potential regulatory roles for this hormone. Future work will be needed to fully elucidate the mechanisms regulating leptin synthesis/release in each tissue as well as its regulatory functions.

引用

页码：357 / 363

页数：6

共 63 条

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