Lessons Learned from Gene Targeting and Transgenesis for Adrenal Physiology and Disease

Axelrod J., Reisine T.D., Stress hormones: Their interaction and regulation, Science, 224, pp. 452-459, (1984)

Chrousos G.P., Gold P.W., The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis, JAMA, 261, pp. 1244-1252, (1992)

Bornstein S.R., Chrousos G.P., Clinical review 104: Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: Neural and immune inputs, J Clin Endocrinol Metab, 84, pp. 1729-1736, (1999)

Muglia L.J., Jacobson L., Dikkes P., Majzoub J.A., Corticotropin releasing hormone deficiency reveals major fetal but not adult glucocorticoid need, Nature, 373, pp. 427-432, (1995)

Muglia L.J., Jacobson L., Weninger S.C., Luedke C.E., Bae D.S., Jeong K.H., Majzoub J.A., Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice, J Clin Invest, 99, pp. 2923-2929, (1997)

Muglia L., Jacobson L., Majzoub J.A., Production of corticotropinreleasing hormone-deficient mice by targeted mutation in embryonic stem cells, Ann NY Acad Sci, 780, pp. 49-59, (1996)

Coste S.C., Kesterson R.A., Heldwein K.A., Stevens S.L., Heard A.D., Hollis J.H., Murray S.E., Hill J.K., Pantely G.A., Hohimer A.R., Hatton D.C., Phillips T.J., Finn D.A., Low M.J., Rittenberg M.B., Stenzel P., Stenzel-Poore M.P., Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2, Nat Genet, 24, pp. 403-409, (2000)

Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M.H.M., Stalla G.K., Blanquet V., Steckler T., Holsboer F., Wurst W., Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1, Nat Genet, 19, pp. 162-166, (1998)

Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H., Chen R., Marchuk Y., Hauser C., Bentley C.A., Sawchenko P.E., Koob G.F., Vale W., Lee K.F., Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and abberant neuroendocrine development, Neuron, 20, pp. 1093-1102, (1998)

Allen R.G., Carey C., Parker J.D., Mortrud M.T., Mellon S.H., Low M.J., Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland, Mol Endocrinol, 9, pp. 1005-1016, (1995)

Axelrod J., Reisine T.D., Stress hormones: Their interaction and regulation, Science, 224, pp. 452-459, (1984)

Chrousos G.P., Gold P.W., The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis, JAMA, 261, pp. 1244-1252, (1992)

Bornstein S.R., Chrousos G.P., Clinical review 104: Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: Neural and immune inputs, J Clin Endocrinol Metab, 84, pp. 1729-1736, (1999)

Muglia L.J., Jacobson L., Dikkes P., Majzoub J.A., Corticotropin releasing hormone deficiency reveals major fetal but not adult glucocorticoid need, Nature, 373, pp. 427-432, (1995)

Muglia L.J., Jacobson L., Weninger S.C., Luedke C.E., Bae D.S., Jeong K.H., Majzoub J.A., Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice, J Clin Invest, 99, pp. 2923-2929, (1997)

Muglia L., Jacobson L., Majzoub J.A., Production of corticotropinreleasing hormone-deficient mice by targeted mutation in embryonic stem cells, Ann NY Acad Sci, 780, pp. 49-59, (1996)

Coste S.C., Kesterson R.A., Heldwein K.A., Stevens S.L., Heard A.D., Hollis J.H., Murray S.E., Hill J.K., Pantely G.A., Hohimer A.R., Hatton D.C., Phillips T.J., Finn D.A., Low M.J., Rittenberg M.B., Stenzel P., Stenzel-Poore M.P., Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2, Nat Genet, 24, pp. 403-409, (2000)

Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M.H.M., Stalla G.K., Blanquet V., Steckler T., Holsboer F., Wurst W., Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1, Nat Genet, 19, pp. 162-166, (1998)

Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H., Chen R., Marchuk Y., Hauser C., Bentley C.A., Sawchenko P.E., Koob G.F., Vale W., Lee K.F., Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and abberant neuroendocrine development, Neuron, 20, pp. 1093-1102, (1998)

Allen R.G., Carey C., Parker J.D., Mortrud M.T., Mellon S.H., Low M.J., Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland, Mol Endocrinol, 9, pp. 1005-1016, (1995)