Metalloproteinases and tissue inhibitors of metalloproteinases

被引：4

作者：

Masakazu Toi

Shinsuke Ishigaki

Takeshi Tominaga

机构：

来源：

Breast Cancer Research and Treatment | 1998年 / 52卷

关键词：

MMP; TIMP; breast cancer; angiogenesis; prognosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Because the proteolytic degradation of extracellular matrix is required for invasion and metastasis, it would appear that the important family of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) might be prognostic indicators of the invasive potential of a breast tumor. Nevertheless, there are few data demonstrating an independent prognostic value of any individual MMPs or TIMPs in primary breast cancer patients. It is possible, however, that the balance among levels of certain MMPs and their inhibitors will be more informative, since MMPs are clearly involved in paracrine tumor-stromal interactions and are associated with angiogenesis, which does appear to be prognostic.

引用

页码：113 / 124

页数：11

共 505 条

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