Nanoparticles - Known and unknown health risks

被引:972
作者
Hoet P.H.M. [1 ]
Brüske-Hohlfeld I. [2 ]
Salata O.V. [3 ]
机构
[1] Katholieke Universiteit Leuven, Depto. de Pneumol. Longtoxicologie, Leuven B-3000
[2] GSF-Forschungszentrum Umwelt/Gesund., D-85764 Neuherberg
[3] Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, South Parks Road
关键词
Stratum Corneum; Fumed Silica; Ultrafine Particle; Diesel Exhaust Particle; Polystyrene Particle;
D O I
10.1186/1477-3155-2-12
中图分类号
学科分类号
摘要
Manmade nanoparticles range from the well-established multi-ton production of carbon black and fumed silica for applications in plastic fillers and car tyres to microgram quantities of fluorescent quantum dots used as markers in biological imaging. As nano-sciences are experiencing massive investment worldwide, there will be a further rise in consumer products relying on nanotechnology. While benefits of nanotechnology are widely publicised, the discussion of the potential effects of their widespread use in the consumer and industrial products are just beginning to emerge. This review provides comprehensive analysis of data available on health effects of nanomaterials. © 2004 Hoet et al; licensee BioMed Central Ltd.
引用
收藏
页数:15
相关论文
共 117 条
  • [41] Singh A.K., Kasinath B.S., Lewis E.J., Interaction of polycations with cell surface negative charges of epithelial cells, Biochim. Biophys. Acta, 1120, pp. 337-342, (1992)
  • [42] Geiser M., Schurch S., Gehr P., Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer, J. Appl. Physiol., 94, pp. 1793-1801, (2003)
  • [43] Gehr P., Geiser M., Hof V.I., Schurch S., Surfactant ultrafine particle interactions: What we can learn from PM10 studies, Phil. Trans. R. Soc. Lond. A, 358, pp. 2707-2718, (2000)
  • [44] Schins R.P., Duffin R., Hohr D., Knaapen A.M., Shi T., Weishaupt C., Stone V., Donaldson K., Borm P.J., Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells, Chem. Res. Toxicol., 15, pp. 1166-1173, (2002)
  • [45] Fubini B., Surface Reactivity in the Pathogenic Response to Particulates, Environ. Health Perspect., 105, pp. 1013-1020, (1997)
  • [46] Yeates D.B., Mauderly J.L., Inhaled environmental/occupational irritants and allergens: Mechanisms of cardiovascular and systemic responses: Introduction, Environ. Health Perspect., 109, pp. 479-481, (2001)
  • [47] Gold D.R., Litonjua A., Schwartz J., Lovett E., Larson A., Nearing B., Allen G., Verrier M., Cherry R., Verrier R., Ambient pollution and heart rate variability, Circulation, 101, pp. 1267-1273, (2000)
  • [48] Liao D., Creason J., Shy C., Williams R., Watts R., Zweidinger R., Daily variation of particulate air pollution and poor cardiac autonomic control in the elderly, Environ. Health Perspect., 107, pp. 521-525, (1999)
  • [49] Conhaim R.L., Eaton A., Staub N.C., Heath T.D., Equivalent pore estimate for the alveolar-airway barrier in isolated dog lung, J. Appl. Physiol., 64, pp. 1134-1142, (1988)
  • [50] Hermans C., Knoops B., Wiedig M., Arsalane K., Toubeau G., Falmagne P., Bernard A., Clara cell protein as a marker of Clara cell damage and bronchoalveolar blood barrier permeability, Eur. Respir. J., 13, pp. 1014-1021, (1999)