Pancreatic function tests: when to choose, what to use.

被引:18
作者
Boeck W.G. [1 ]
Adler G. [1 ]
Gress T.M. [1 ]
机构
[1] Department of Internal Medicine I, University of Ulm, Robert-Koch-Str. 8, Ulm
关键词
Chronic Pancreatitis; Secretin; Pancreatic Function; Pancreatic Insufficiency; Exocrine Pancreatic Function;
D O I
10.1007/s11894-001-0004-9
中图分类号
学科分类号
摘要
Although techniques for high-resolution imaging of the pancreas are constantly being improved, the evaluation of pancreatic function remains crucial for the workup of pancreatic diseases. More than 20 direct and indirect tests are available for the assessment of pancreatic function. Measurement of fecal elastase-1 is recommended as the most suitable test for the initial assessment of pancreatic function. Among other techniques, the pancreolauryl test, and alternatively the BT-PABA (N-benzoyl-L-tyrosyl-p-aminobenzoic acid) or the (13)C-mixed-triglyceride test, yield the best sensitivity and specificity. Nevertheless, all indirect tests are of limited value in patients with mild to moderate impairment of pancreatic function. In these patients, the secretin-caerulein test remains the gold standard.
引用
收藏
页码:95 / 100
页数:5
相关论文
共 121 条
[11]  
Stanescu A(1996)Faecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test Gut 39 580-586
[12]  
Ditschuneit H(1999)Fecal elastase 1 determination in chronic pancreatitis Dig Dis Sci 44 210-213
[13]  
Malfertheiner P(1998)Faecal elastase 1: not helpful in diagnosing chronic pancreatitis associated with mild to moderate exocrine pancreatic insufficiency Gut 42 551-554
[14]  
Büchler M(1989)The fecal chymotrypsin photometric assay in the evaluation of exocrine pancreatic capacity: comparison with other direct and indirect pancreatic function tests Pancreas 4 300-304
[15]  
Lankisch PG(1999)Diagnostic value of fecal elastase test in pancreatic exocrine deficiency Orv Hetil 140 1887-1890
[16]  
Schmidt I(1999)Comparison of fecal elastase-1 determination with the secretin-cholecystokinin test in patients with cystic fibrosis Scand J Gastroenterol 34 202-207
[17]  
Dimagno EP(1997)Duodenal secretion and fecal excretion of pancreatic elastase-1 in healthy humans and patients with chronic pancreatitis Pancreas 15 191-200
[18]  
Go VL(1996)Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function Clin Chem 42 222-226
[19]  
Summerskill WH(2000)Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis Pediatr Pulmonol 29 172-176
[20]  
Niederau C(1999)Faecal elastase 1: a marker of exocrine pancreatic insufficiency in cystic fibrosis Ann Clin Biochem 36 739-742