New insights into the pathogenesis of systemic lupus erythematosus.

被引：22

作者：

Kyttaris V.C. ^{[1
]}

Katsiari C.G. ^{[1
]}

Juang Y.T. ^{[1
]}

Tsokos G.C. ^{[1
]}

机构：

[1] Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, 20910, MD

来源：

Current Rheumatology Reports | 2005年 / 7卷 / 6期

关键词：

Systemic Lupus Erythematosus; Systemic Lupus Erythematosus Patient; Mannose Binding Lectin; Chain mRNA; Temic Lupus Erythematosus;

D O I：

10.1007/s11926-005-0054-3

中图分类号：

学科分类号：

摘要：

Although the etiology of systemic lupus erythematosus is unknown, recent studies have shed light on the pathogenetic pathways that lead to tissue damage. The immune system in systemic lupus erythematosus is characterized by a complex interplay between overactive B cells, abnormally activated T cells, and antigen-presenting cells. This leads to the production of an array of inflammatory cytokines, diverse autoantibodies, and immune complexes that in turn activate effector cells and the complement system leading to the clinical manifestations of the disease.

引用

页码：469 / 475

页数：6

共 181 条

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