New insights into the pathogenesis of systemic lupus erythematosus.

被引：22

作者：

Kyttaris V.C. ^{[1
]}

Katsiari C.G. ^{[1
]}

Juang Y.T. ^{[1
]}

Tsokos G.C. ^{[1
]}

机构：

[1] Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, 20910, MD

来源：

Current Rheumatology Reports | 2005年 / 7卷 / 6期

关键词：

Systemic Lupus Erythematosus; Systemic Lupus Erythematosus Patient; Mannose Binding Lectin; Chain mRNA; Temic Lupus Erythematosus;

D O I：

10.1007/s11926-005-0054-3

中图分类号：

学科分类号：

摘要：

Although the etiology of systemic lupus erythematosus is unknown, recent studies have shed light on the pathogenetic pathways that lead to tissue damage. The immune system in systemic lupus erythematosus is characterized by a complex interplay between overactive B cells, abnormally activated T cells, and antigen-presenting cells. This leads to the production of an array of inflammatory cytokines, diverse autoantibodies, and immune complexes that in turn activate effector cells and the complement system leading to the clinical manifestations of the disease.

引用

页码：469 / 475

页数：6

共 181 条

[11]

Davies KA(2001)Advances in immunology: complement, second of two parts N Engl J Med 344 1140-1144

[12]

Norsworthy PJ(1996)Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus Arthritis Rheum 39 2046-2051

[13]

Kyttaris V(1995)Mannose-binding protein gene polymorphism in systemic lupus erythemato-sus Arthritis Rheum 38 110-114

[14]

Tsokos G(1997)A dysfunctional allele of the mannose binding protein gene associates with systemic lupus erythematosus in a Spanish population J Rheumatol 24 485-488

[15]

Wilson AG(2003)The genetics of human systemic lupus erythemato-sus Tre nds I mmunol 24 595-602

[16]

Gordon C(2005)Genetics of systemic lupus erythematosus: how far have we come Rheum Dis Clin North Am 31 223-244

[17]

di Giovine FS(2005)CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis Hum Genet 116 361-367

[18]

Morita C(2005)A stop codon polymor-phism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus Proc Natl Acad Sci U S A 102 10593-10597

[19]

Horiuchi T(1999)The role of sex hormones in systemic lupus erythematosus Curr Opin Rheumatol 11 352-356

[20]

Tsukamoto H(2000)Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells PNAS 97 2703-2708

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