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Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials

被引：62
作者：
Mark Bloomston
Emmanuel E. Zervos
Alexander S. Rosemurgy
机构：
[1] University of South Florida,Department of Surgery
来源：
Annals of Surgical Oncology | 2002年 / 9卷 / 7期
关键词：
Pancreatic cancer; Matrix metalloproteinase; MMP; TIMP;
D O I：
10.1007/BF02574483
中图分类号：
学科分类号：
摘要：
Matrix metalloproteinases (MMPs) have received much attention in recent years for their role in a variety of malignancies. Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. Inhibition of MMPs has shown great promise with synthetic inhibitors, such as BB-94, as tumorostatic agents in preclinical models, particularly when these are combined with gemcitabine. These findings have led to several clinical trials using the MMP inhibitors Marimastat and BAY 12-9566. Herein, we discuss the roles of MMPs and their inhibition in pancreatic cancer.
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页码：668 / 674
页数：6
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