Vulvovaginal Candidiasis caused by non-albicans Candida species: New insights

被引：87

作者：

Kennedy M.A. ^{[1
]}

Sobel J.D. ^{[1
]}

机构：

[1] Division of Infectious Diseases, Wayne State University, School of Medicine, Detroit, MI

来源：

Current Infectious Disease Reports | 2010年 / 12卷 / 6期

关键词：

Candida albicans; Candida glabrata; Candida parapsilosis; Candida species; Non-albicans Candida; Vaginitis; Vulvovaginal candidiasis;

D O I：

10.1007/s11908-010-0137-9

中图分类号：

学科分类号：

摘要：

Non-albicans Candida species have increasingly been identified as the cause of vulvovaginitis. In vitro and in vivo data indicate that the various non-albicans Candida species identified in the lower genital tract differ considerably with regard to epidemiology, virulence or vaginal pathogenicity, and antimycotic drug susceptibility. Clinical experience indicates reduced virulence of these organisms in the lower genital tract, and their causal role in a symptomatic patient requires careful case-by-case determination rather than routine administration of antimycotic therapy. Accordingly, vaginal Candida isolates deserve species identification and consideration of pathogenic potential and antifungal susceptibility before therapeutic decisions are made. © 2010 Springer Science+Business Media, LLC.

引用

页码：465 / 470

页数：5

共 16 条

[11] Singh S., Sobel J.D., Bhargava P., Boikov D., Vazquez J.A., Vaginitis due to Candida krusei: Epidemiology, clinical aspects, and therapy, Clinical Infectious Diseases, 35, 9, pp. 1066-1070, (2002)
[12] Sobel J.D., Chaim W., Nagappan V., Leaman D., Treatment of vaginitis caused by Candida glabrata: Use of topical boric acid and flucytosine, American Journal of Obstetrics and Gynecology, 189, 5, pp. 1297-1300, (2003)
[13] Richter S.S., Galask R.P., Messer S.A., Hollis R.J., Diekema D.J., Pfaller M.A., Antifungal susceptibilities of Candida species causing vulvovaginitis and epidemiology of recurrent cases, Journal of Clinical Microbiology, 43, 5, pp. 2155-2162, (2005)
[14] Sobel J.D., Management of infections caused by Candida glabrata, Curr Infect Dis Rep, 2, pp. 424-428, (2000)
[15] Pfaller M.A., Diekema D.J., Gibbs D.L., Et al., Global Antifungal Surveillance Group: Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: An assessment from the ARTEMIS DISK Global Antifungal Surveillance Program, Diagn Microbiol Infect Dis, 67, pp. 162-171, (2010)
[16] Nyirjesy P., Alexander A.B., Weitz M.V., Vaginal Candida parapsilosis: Pathogen or bystander?, Infect Dis Obstet Gynecol, 13, pp. 37-41, (2005)

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