Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB

被引：3

作者：

Philipp Haus-Seuffert

Michael Meisterernst

机构：

[1] Institute of Molecular Immunology,Department for Proteinbiochemistry, GSF

来源：

Molecular and Cellular Biochemistry | 2000年 / 212卷

关键词：

transcriptional regulation; gene expression; coactivator; repressor;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context- and position-specific function of CREB on complex genes.

引用

页码：5 / 9

页数：4

共 189 条

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