Coronary heart disease and polymorphisms in genes affecting lipid metabolism and inflammation

被引：13

作者：

Cambien F. ^{[1
]}

机构：

[1] INSERM U525, Chu Pitié-Salpétrière Université Pierre et Marie Curie, 75013 Paris

来源：

Current Atherosclerosis Reports | 2005年 / 7卷 / 3期

关键词：

Cholesteryl Ester Transfer Protein; Familial Hypercholesterolemia; Arterioscler Thromb Vasc Biol; ABCA1 Gene; Cholesteryl Ester Transfer Protein Activity;

D O I：

10.1007/s11883-005-0005-5

中图分类号：

学科分类号：

摘要：

Several biologic systems contribute to the pathophysiology of atherosclerosis and its complications, and within each of these systems many genes have been explored to establish the possible implication of their variability in coronary heart disease (CHD) risk. This report is focused on recent results pertaining to lipid and inflammatory genes, their variability, and their relationship with intermediate phenotypes and CHD. For both systems, there is no evidence at the present time that testing genetic polymorphisms might be of any benefit to the patient, for the diagnosis or prognosis of CHD, or for tailoring drug prescription. Understanding the genetics of complex traits like CHD will require a system approach that allows a modeling of the interaction among genes as well as between genetic and nongenetic sources of variation. Copyright © 2005 by Current Science Inc.

引用

页码：188 / 195

页数：7

共 78 条

[1]

Berglund L., Ramakrishnan R., Lipoprotein(a): An elusive cardiovascular risk factor, Arterioscler. Thromb. Vasc. Biol., 24, pp. 2219-2226, (2004)

[2]

Morabia A., Cayanis E., Costanza M.C., Et al., Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors, Hum. Mol. Genet., 12, pp. 2733-2743, (2003)

[3]

Knoblauch H., Bauerfeind A., Toliat M.R., Et al., Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol, Hum. Mol. Genet., 13, pp. 993-1004, (2004)

[4]

Wang X., Paigen B., Genetics of variation in HDL cholesterol in humans and mice, Circ. Res., 96, pp. 27-42, (2005)

[5]

Austin M.A., Hutter C.M., Zimmern R.L., Humphries S.E., Genetic causes of monogenic heterozygous familial hypercholesterolemia: A HuGE prevalence review, Am. J. Epidemiol., 160, pp. 407-420, (2004)

[6]

Song Y., Stampfer M.J., Liu S., Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease, Ann. Inter. Med., 141, pp. 137-147, (2004)

[7]

Boekholdt S.M., Kuivenhoven J., Wareham N.J., Et al., Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: The prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study, Circulation, 110, pp. 1418-1423, (2004)

[8]

Corbex M., Poirier O., Fumeron F., Et al., Extensive association analysis between the CETP gene and coronary heart disease phenotypes reveals several putative functional polymorphisms and gene-environment interaction, Genet. Epidemiol., 19, pp. 64-80, (2000)

[9]

Thompson J.F., Lira M.E., Durham L.K., Et al., Polymorphisms in the CETP gene and association with CETP mass and HDL levels, Atherosclerosis, 167, pp. 195-204, (2003)

[10]

Dachet C., Poirier O., Cambien F., Et al., New functional promoter polymorphism, CETP/-629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotein cholesterol levels: Role of Sp1/Sp3 in transcriptional regulation, Arterioscler. Thromb. Vasc. Biol., 20, pp. 507-515, (2000)

← 1 2 3 4 5 6 7 8 →