Coronary heart disease and polymorphisms in genes affecting lipid metabolism and inflammation

被引：13

作者：

Cambien F. ^{[1
]}

机构：

[1] INSERM U525, Chu Pitié-Salpétrière Université Pierre et Marie Curie, 75013 Paris

来源：

Current Atherosclerosis Reports | 2005年 / 7卷 / 3期

关键词：

Cholesteryl Ester Transfer Protein; Familial Hypercholesterolemia; Arterioscler Thromb Vasc Biol; ABCA1 Gene; Cholesteryl Ester Transfer Protein Activity;

D O I：

10.1007/s11883-005-0005-5

中图分类号：

学科分类号：

摘要：

Several biologic systems contribute to the pathophysiology of atherosclerosis and its complications, and within each of these systems many genes have been explored to establish the possible implication of their variability in coronary heart disease (CHD) risk. This report is focused on recent results pertaining to lipid and inflammatory genes, their variability, and their relationship with intermediate phenotypes and CHD. For both systems, there is no evidence at the present time that testing genetic polymorphisms might be of any benefit to the patient, for the diagnosis or prognosis of CHD, or for tailoring drug prescription. Understanding the genetics of complex traits like CHD will require a system approach that allows a modeling of the interaction among genes as well as between genetic and nongenetic sources of variation. Copyright © 2005 by Current Science Inc.

引用

页码：188 / 195

页数：7

共 78 条

[41]

Schieffer B., Selle T., Hilfiker A., Et al., Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis, Circulation, 110, pp. 3493-3500, (2004)

[42]

Rivera-Chavez F.A., Peters-Hybki D.L., Barber R.C., O'Keefe G.E., Interleukin-6 promoter haplotypes and interleukin-6 cytokine responses, Shock, 20, pp. 218-223, (2003)

[43]

Lieb W., Pavlik R., Erdmann J., Et al., No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors, Int. J. Cardiol., 97, pp. 205-212, (2004)

[44]

Basso F., Lowe G.D., Rumley A., Et al., Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS), Arterioscler. Thromb. Vasc. Biol., 22, pp. 599-604, (2002)

[45]

Brull D., Montgomery H., Sanders J., Et al., Interleukin-6 gene-174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery, Arterioscler. Thromb. Vasc. Biol., 21, pp. 1458-1463, (2001)

[46]

Georges J.L., Rupprecht H.J., Blankenberg S., Et al., Impact of pathogen burden in patients with coronary artery disease in relation to systemic inflammation and variation in genes encoding cytokines, Am. J. Cardiol., 92, pp. 515-521, (2003)

[47]

Lang R., Patel D., Morris J.J., Et al., Shaping gene expression in activated and resting primary macrophages by IL-10, J. Immunol., 169, pp. 2253-2263, (2002)

[48]

Caligiuri G., Rudling M., Ollivier V., Et al., Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice, Mol. Med., 9, pp. 10-17, (2003)

[49]

Heeschen C., Dimmeler S., Hamm C.W., Et al., Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes, Circulation, 107, pp. 2109-2114, (2003)

[50]

Reuss E., Fimmers R., Kruger A., Et al., Differential regulation of interleukin-10 production by genetic and environmental factors-a twin study, Genes Immunol., 3, pp. 407-413, (2002)

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