Significance of leukoaraiosis. Current status and differential diagnosis

被引：5

作者：

Bischoff Ch. ^{[1
,3
]}

Von Einsiedel H.G. ^{[2
]}

机构：

[1] Neurologische Klinik, Technische Universitat, München

[2] Abteilung für Neuroradiologie, Technische Universitat Munchen

[3] Neurologische Klinik, Technischen Universität, D-81675 Munchen

来源：

Der Nervenarzt | 1997年 / 68卷 / 8期

关键词：

Binswanger's disease; Dementia; Leukoaraiosis; Leukoencephalopathy; White matter lesions;

D O I：

10.1007/s001150050170

中图分类号：

学科分类号：

摘要：

Bilateral symmetric changes in the cerebral hemispheric white matter are found with increasing frequency using CT and MRI techniques. These unspecific canges of the white matter signal are often called leukoaraiosis. They differ from the normal white matter signal. These changes are found with in-creasing frequency in persons older than 60 years and also patients with dementia and cerebrovascular diseases. The pathogenesis, clinical significance and morphological substrate are unclear. The aim of this review is to summarise the actual knowledge about the etiology and clinical signs and symptoms found in patients with leukoaraiosis. This term should not be used when white matter changes are found in patients younger than 35 years, with an unilateral onset, asymmetric distribution, and extensive changes all over the infra- and supratentorial white matter area. Neuroradiological and clinical criteria are given to differentiate between leukoaraiosis and diseases of the white matter, especially enlarged Virchow-Robin spaces, lacunar infarction, subcortical arteriosclerotic angiopathy (Binswanger's disease), leukoencephalopathy of different origin, and demyelinating diseases.

引用

页码：609 / 619

页数：10

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