The role of neuroeffector mechanisms in the pathogenesis of asthma

被引：25

作者：

Joos G.F. ^{[1
]}

机构：

[1] Department of Respiratory Diseases 7K12E, Ghent University Hospital, De Pintelaan 185, Ghent

来源：

Current Allergy and Asthma Reports | 2001年 / 1卷 / 2期

关键词：

Airway Smooth Muscle; Capsaicin; Leukemia Inhibitory Factor; Nerve Growth Factor; Vasoactive Intestinal Peptide;

D O I：

10.1007/s11882-001-0081-8

中图分类号：

学科分类号：

摘要：

Neural regulation of the airways consists of cholinergic excitatory, adrenergic inhibitory nerves and nonadrenergic, noncholinergic (NANC) nerves. NANC nerves can be either inhibitory or excitatory. Cholinergic nerves form the predominant bronchoconstrictor neural pathway in human airways. Acetylcholine controls neuronal and nonneuronal target cells via a short-lived action at nicotinic and muscarinic receptors. The most important control over acetylcholine release from postganglionic cholinergic nerves is exerted by acetylcholine itself. The M2 autoreceptor is located prejunctionally on postganglionic nerves. Its stimulation limits the further release of acetylcholine. A loss of function in the neuronal muscarinic M2 autoreceptor occurs after exposure to allergen, ozone, or viruses. In human airways, inhibitory NANC (i-NANC) mechanisms are the only neural bronchodilatory mechanisms. The presumed neurotransmitters of the i-NANC system are vasoactive intestinal peptide and nitric oxide. Substance P and neurokinin A have been implicated as the neurotransmitters mediating the excitatory part of the NANC nervous system. NK2 receptors are present on smooth muscle of both large and small airways and mediate part of the bronchoconstrictor effect of tachykinins. Most of the proinflammatory effects of substance P are mediated by the NK1 receptor. Tachykinin receptor antagonists are currently being developed as a possible anti-asthma treatment. An extensive cross-talk exists between nerves and the immune system. The complexity of the picture has increased further as it has become clear that classical neurotransmitters, such as acetylcholine and neuropeptides, are produced by nonneuronal cells. © 2001, Current Science Inc.

引用

页码：134 / 143

页数：9

共 78 条

[51] Cooke H.J., Fox P., Alferes L., Et al., Presence of NK1 receptors on a mucosal-like mast cell line, RBL-2H3 cells, Can J Physiol Pharmacol, 76, pp. 188-193, (1998)
[52] Forsythe P., McGarvey L.P., Heaney L.G., Et al., Sensory neuropeptides induce histamine release from bronchoalveolar lavage cells in both nonasthmatic coughers and cough variant asthmatics, Clin Exp Allergy, 30, pp. 225-232, (2000)
[53] Okada T., Hirayama Y., Kishi S., Et al., Functional neurokinin NK-1 receptor expression in rat peritoneal mast cells, Inflamm Res, 48, pp. 274-279, (1999)
[54] Marriott I., Mason M.J., Elhofy A., Et al., Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells, J Neuroimmunol, 102, pp. 163-171, (2000)
[55] Kradin R., MacLean J., Duckett S., Et al., Pulmonary response to inhaled antigen: neuroimmune interactions promote the recruitment of dendritic cells to the lung and the cellular immune response to inhaled antigen, Am J Pathol, 150, pp. 1735-1743, (1997)
[56] Schuiling M., Zuidhof A., Zaagsma J., Et al., Involvement of tachykinin NK1 receptor in the development of allergeninduced airway hyperreactivity and airway inflammation in conscious, unrestrained guinea-pigs, Am J Respir Crit Care Med, 159, pp. 423-430, (1999)
[57] Schuiling M., Zuidhof A., Meurs H., Et al., Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammation cell influx in conscious, unrestrained guinea-pigs, Br J Pharmacol, 127, pp. 1030-1038, (1999)
[58] Maghni K., Taha R., Afif W., Et al., Dichotomy between neurokinin receptor actions in modulating allergic airway responses in an animal model of helper T cell type 2 cytokine-associated inflammation, Am J Respir Crit Care Med, 162, pp. 1068-1074, (2000)
[59] Ichinose M., Nakajima N., Takahashi T., Et al., Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist, Lancet, 340, pp. 1248-1251, (1992)
[60] Joos G.F., Van Schoor J., Kips J.C., Et al., The effect of inhaled FK244, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics, Am J Respir Crit Care Med, 153, pp. 1781-1784, (1996)

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