HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease

被引：36

作者：

Brewer Jr. H.B. ^{[1
]}

机构：

[1] Department of Lipoprotein and Atherosclerosis Research, Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010

来源：

Current Cardiology Reports | 2007年 / 9卷 / 6期

关键词：

Atorvastatin; Cholesteryl Ester Transfer Protein; Cholesterol Efflux; Acute Coronary Syndrome Patient; Torcetrapib;

D O I：

10.1007/BF02938393

中图分类号：

学科分类号：

摘要：

Developing new therapeutic approaches to treating residual cardiovascular risk of recurrent clinical events in statin-treated patients has been a major challenge for the cardiovascular field. Data from epidemiological evidence, animal models, and initial clinical trials indicate that increasing high-density lipoprotein (HDL) may be an effective new target for treating residual cardiovascular risk. Over the past several years, major advances have occurred in our understanding of HDL metabolism and of the important roles of the ABCA1 and ABCG1 transporters as well as the SR-BI receptor in cholesterol transport. Current approaches to HDL therapy include acute HDL infusion therapy in acute coronary syndrome patients and chronic oral HDL therapy in stable patients with cardiovascular disease. Definitive clinical trials will now be required to establish the safety and efficacy of increasing HDL in the treatment of patients with cardiovascular disease. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：486 / 492

页数：6

共 71 条

[41]

Venkateswaran A., Laffitte B.A., Joseph S.B., Et al., Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha, Proc Natl Acad Sci U S A, 97, pp. 12097-12102, (2000)

[42]

Schwartz K., Lawn R.M., Wade D.P., ABC1 gene expression and apoA-I-mediated cholesterol efflux are regulated by LXR, Biochem Biophys Res Commun, 274, pp. 794-802, (2000)

[43]

Costet P., Luo Y., Wang N., Tall A.R., Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor, J Biol Chem, 275, pp. 28240-28245, (2000)

[44]

Chawla A., Boisvert W.A., Lee C.H., Et al., A PPAR gnmma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis, Mol Cell, 7, pp. 161-171, (2001)

[45]

Wang N., Ranalletta M., Matsuura F., Et al., LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL, Arterioscler Thromb Vasc Biol, 26, pp. 1310-1316, (2006)

[46]

Schwartz C.C., Vlahcevic Z.R., Halloran L.G., Swell L., An in vivo evaluation in man of the transfer of esterified cholesterol between lipoproteins and into the liver and bile, Biochim Biophys Acta, 663, pp. 143-162, (1981)

[47]

Santamarina-Fojo S., Haudenschild C., Amar M., The role of hepatic lipase in lipoprotein metabolism and atherosclerosis, Curr Opin Lipidol, 9, pp. 211-219, (1998)

[48]

Huuskonen J., Oikkonen V.M., Jauhiainen M., Ehnholm C., The impact of phospholipid transfer protein (PLTP) on HDL metabolism, Atherosclerosis, 155, pp. 269-281, (2001)

[49]

Jahangiri A., Rader D.J., Marchadier D., Et al., Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I, J Lipid Res, 46, pp. 896-903, (2005)

[50]

Barter P.J., Baker P.W., Rye K.A., Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells, Curr Opin Lipidol, 13, pp. 285-288, (2002)

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