Premorbid body weight and its relations to primary tumour diameter in breast cancer patients; its dependence on estrogen and progesteron receptor status

被引：50

作者：

Ove Mæhle B. ^{[1
]}

Tretli S. ^{[2
]}

Skjærven R. ^{[3
]}

Thorsen T. ^{[4
]}

机构：

[1] Gade Institute, Department of Pathology, Bergen

[2] Cancer Registry of Norway, Institute of Epidemiological Cancer Research, Montebello, Oslo

[3] Section for Medical Informatics and Statistics, Bergen

[4] Hormone Laboratory, University of Bergen, Haukeland Hospital, Bergen

来源：

Breast Cancer Research and Treatment | 2001年 / 68卷 / 2期

关键词：

Body weight; Breast cancer; Estrogen receptor status; Progesteron receptor status; Quetelet's index; Tumour diameter;

D O I：

10.1023/A:1011977118921

中图分类号：

学科分类号：

摘要：

Hormonal mechanisms have been offered as an explanation for the higher frequency of large tumours, lymph node metastases and poorer prognosis in obese breast cancer patients than in lean ones. If hormonal mechanisms are important for these relations, they should probably act more strongly in patients with hormonal receptor positive tumours than in those with negative ones. We have examined if the relations between premorbid body weight or Quetelet's index (weight/height2) and tumour diameter are modified by estrogen receptor alpha (ER) and progesteron receptor (PgR) status. The analyses were based on 1, 241 women with unilateral disease treated with modified radical mastectomy living in the geografic area of Haukeland Hospital. Their body weight and height have been measured as a mean 12.5 years before presentation of the disease. Body weight and Quetelet's index have been adjusted for age. The relations were studied using linear regression analyses adjusting the effect of body weight with height and mean nuclear area of the tumour cells and adjusting the effect of Quetelet's index for mean nuclear area. The main findings showed that patients with high body weight or Quetelet's index presented more often with PgR positive tumours than lean ones. Quetelet's index was also positively related to ER. These relations were present in patients older than 50 years of age (older). Patients with large tumours (>2.0 cm) had significantly higher body weight and Quetelet's index than those with small ones. These differences were significantly present in older patients and in patients with PgR negative and ER negative - PgR negative tumours. Linear regression analyses confirmed that tumour diameter increases with body weight and Quetelet's index. These relations were present in both lymph node groups and in older patients. Stratification according to hormonal receptor status showed these relations to be significant in patients with ER negative, with PgR negative and those with ER negative - PgR negative tumours only. Taking age and hormonal receptor status into consideration simultaneously, both body weight and Quetelet's index were significantly related to tumour diameter in older patients with hormone receptor negative tumours. In conclusion body size was positively related to hormone receptor status and to diameter of the primary tumour. The relation to tumour diameter was present in older patients with hormone receptor negative tumours. Although hormonal mechanisms able to act on the tumour can not be excluded, mechanisms acting independent of hormonal receptors must be considered. Different mechanisms related to body fat cytokines are discussed.

引用

页码：159 / 169

页数：10

共 53 条

[11]

Senie R.T., Rosen P.P., Rhodes P., Lesser M.L., Kinne D.W., Obesity at diagnosis of breast carcinoma influences duration of disease-free survival, Ann Intern Med, 116, pp. 26-32, (1992)

[12]

Tretli S., Height and weight in relation to breast cancer morbidity and mortality. A prospective study of 570, 000 women in Norway, Int J Cancer, 44, pp. 23-30, (1989)

[13]

Boyd N.F., Campbell J.E., Germanson T., Thomson D.B., Sutherland D.J., Meakin J.W., Body weight and prognosis in breast cancer, JNCI, 67, pp. 785-789, (1981)

[14]

Tartter P.I., Papatestas A.E., Ioannovich J., Mulvihill M.N., Lesnick G., Aufses A.H., Cholesterol and obesity as prognostic factors in breast cancer, Cancer, 47, pp. 2222-2227, (1981)

[15]

Hebert J.R., Augustine A., Barone J., Kabat G.C., Kinne D.W., Wynder E.L., Weight, height and body mass index in the prognosis of breast cancer: Early results of a prospective study, Int J Cancer, 42, pp. 315-318, (1988)

[16]

Kyogoku S., Hirohata T., Takeshita S., Nomura Y., Shigematsu T., Horie A., Survival of breast-cancer patients and body size indicators, Int J Cancer, 46, pp. 824-831, (1990)

[17]

Vatten L.J., Foss O.P., Kvinnsland S., Overall survival of breast cancer patients in relation to preclinically determined total serum cholesterol, body mass index, height and cigarette smoking: A population-based study, Eur J Cancer, 27, pp. 641-646, (1991)

[18]

Cleland W.H., Mendelson C.R., Simpson E.R., Effects of aging and obesity on aromatase activity of human adipose cells, J Clin Endocrin Metab, 60, 1, pp. 174-177, (1985)

[19]

Enriori C.L., Orsini W., Cremona M.D.C., Etkin A.E., Cardillo L.R., Reforzo-Membrives J., Decrease of circulating level of SHBG in postmenopausal obese women as a risk factor in breast cancer: Reversible effect of weight loss, Gynecol Oncol, 23, pp. 77-86, (1986)

[20]

Reed M.J., Purohit A., Breast cancer and the role of cytokines in regulating estrogen synthesis: An emerging hypothesis, Endocrine Reviews, 18, 5, pp. 701-715, (1997)

← 1 2 3 4 5 6 →