The utility of functional magnetic resonance imaging in epilepsy and language

被引：11

作者：

Balsamo L.M. ^{[1
,2
]}

Gaillard W.D. ^{[1
,2
]}

机构：

[1] Department of Neurology, Children’s National Medical Center, Washington, DC, 20010

[2] Epilepsy Research Branch, NINDS, NIH, Bethesda, MD

来源：

Current Neurology and Neuroscience Reports | 2002年 / 2卷 / 2期

基金：

美国国家卫生研究院;

关键词：

Temporal Lobe Epilepsy; Inferior Frontal Gyrus; Functional Magnetic Resonance Image; Asymmetry Index; Verbal Fluency Task;

D O I：

10.1007/s11910-002-0023-4

中图分类号：

学科分类号：

摘要：

Functional magnetic resonance imaging (fMRI) is a viable presurgical tool for use with the pediatric epilepsy population as replacement for the intra-carotid sodium amobarbital test (IAT) used to identify hemispheric language dominance. This paper reviews the current imaging research on the identification of language cortex in pediatric epilepsy patients and in normal children. A review of the literature comparing fMRI to the IAT and electrocortical stimulation suggests that fMRI reliably identifies the dominant hemisphere, with pediatric and adult studies producing comparable results. Within-hemisphere localization of eloquent cortex with fMRI is more problematic. Paradigm selection, data analysis techniques, and considerations specific to imaging children are discussed. Utility of fMRI for studying neural plasticity as a result of brain insult (e.g., epilepsy) is also considered.

引用

页码：142 / 149

页数：7

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