The Therapeutic Value of Somatostatin and Its Analogues

被引:4
作者
Farooqi S. [1 ]
Bevan J.S. [2 ]
Sheppard M.C. [3 ]
Wass J.A.H. [4 ,5 ]
机构
[1] Department of Medicine, Addenbrooke's Hospital, Cambridge
[2] Aberdeen Royal Infirmary, Aberdeen
[3] Queen Elizabeth Hospital, Birmingham
[4] Department of Endocrinology, Radcliffe Infirmary, Oxford
[5] Department of Endocrinology, Radcliffe Infirmary, Woodstock Road, Oxford
关键词
D O I
10.1023/A:1009978106476
中图分类号
学科分类号
摘要
In this review we discuss the physiological effects of somatostatin, which are mediated by specific receptor subtypes on different tissues. These observations have suggested new therapeutic possibilities for the use of the synthetic somatostatin analogues in the treatment of acromegaly as well as a number of other endocrine and non-endocrine disorders.
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页码:79 / 88
页数:9
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共 97 条
[91]  
Thornton, P.S., Alter, C.A., Levin Katz, L.E., Short and long term use of octreotide in the treatment of congenital hyperinsulinism (1993) Pediatrics, 123, pp. 637-643
[92]  
Lamberts, S.W.J., Pieters, G.F.F.M., Metselaar, H.J., Ong, G.L., Tan, H.S., Reubi, J.C., Development of resistance to a long-acting somatostatin analogue during treatment of two patients with metastatic endocrine pancreatic tumours (1988) Acta Endocrinol, 119, pp. 561-566
[93]  
Sassolas, G., The role of sandostatin in acromegaly (1992) Metabolism, 41, pp. 39-43
[94]  
Dowling, R.H., Hussaini, S.H., Murphy, G.M., Besser, G.M., Wass, J.A.H., Gallstones during octreotide therapy (1992) Metabolism, 41, pp. 22-33
[95]  
Creutzfeldt, W., Lembeke, B., Folsch, U.R., Schleser, S., Koop, I., Effect of somatostatin analogue (SMS 201-995, Sandostatin) on pancreatic secretion in humans (1987) Am J Med, 82, pp. 9-59
[96]  
Londong, W., Angerer, M., Kutz, K., Landgraf, R., Londong, V., Diminishing efficacy of octreotide (SMS 201-995) on gastric functions of healthy subjects during one-week administration (1989) Gastroenterology, 96, pp. 713-722
[97]  
Patel, Y.C., Greenwood, M.T., Warszynska, A., Panetta, R., Srikant, C.B., All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase (1994) Biochem Biophys Res Commun, 198, pp. 605-612