What causes the antiphospholipid syndrome?

被引：8

作者：

Merrill J.T. ^{[1
]}

机构：

[1] Division of Rheumatology, St. Luke's-Roosevelt Hospital Center, Antenucci Building, 432 West 58th Street, New York, 10019, NY

来源：

Current Rheumatology Reports | 2001年 / 3卷 / 4期

关键词：

Systemic Lupus Erythematosus; Factor Versus Leiden Mutation; Systemic Lupus Erythe; Lupus Anticoagulant; Mature High Density Lipoprotein;

D O I：

10.1007/s11926-001-0033-2

中图分类号：

学科分类号：

摘要：

The antiphospholipid syndrome (APS) is characterized by unpredictable, sporadic, thrombotic events. The cause of the thrombosis is probably multifactorial and may involve disparate effects of the autoantibodies associated with the syndrome, which are known to interfere with various protein regulators of hemostasis. An integrated theory of pathogenesis that accounts for the diversity of autoantibodies and their effects suggests that cellular inflammation or apoptosis within the vasculature may lead to oxidation or turnover in phospholipid membranes. Thus, normally cryptic, functionally important epitopes of phospholipid-binding proteins are subjected to increased exposure to immune surveillance.

引用

页码：293 / 300

页数：7

共 331 条

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