Pleiotropic effects of fibrates

被引：35

作者：

Chinetti-Gbaguidi G. ^{[1
]}

Fruchart J.C. ^{[1
]}

Staels B. ^{[1
]}

机构：

[1] UR 545 INSERM, Institut Pasteur de Lille, 59019 Lille

来源：

Current Atherosclerosis Reports | 2005年 / 7卷 / 5期

关键词：

Inflammatory Cytokine; Intervention Trial; Pleiotropic Effect; Combine Action; Phase Response;

D O I：

10.1007/s11883-005-0053-x

中图分类号：

学科分类号：

摘要：

Fibrates are a widely used class of hypolipidemic drugs. The effects of fibrates are mediated through the activation of the transcription factor peroxisome proliferator-activated receptor α (PPARα). Fibrates act to modulate the transcription of genes that encode proteins controlling lipid transport and metabolism. Fibrates also exert pleiotropic anti-inflammatory effects by downregulating expression of genes encoding inflammatory cytokines and acute phase response proteins. These combined actions translate into clinical benefit as demonstrated by the reduction in cardiovascular morbidity and mortality in primary and secondary intervention trials. Copyright © 2005 by Current Science Inc.

引用

页码：396 / 401

页数：5

共 58 条

[21] Li L., Beauchamp M.C., Renier G., Peroxisome proliferator-activated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression, Atherosclerosis, 165, pp. 101-110, (2002)
[22] Chinetti G., Lestavel S., Fruchart J.C., Et al., Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages, Circ. Res., 92, pp. 212-217, (2003)
[23] Ghosh S., Natarajan R., Cloning of the human cholesteryl ester hydrolase promoter: Identification of functional peroxisomal proliferator-activated receptor responsive elements, Biochem. Biophys. Res. Commun., 284, pp. 1065-1070, (2001)
[24] Chinetti G., Zawadski C., Fruchart J.C., Staels B., Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR, Biochem. Biophys. Res. Commun., 314, pp. 151-158, (2004)
[25] Delerive P., Gervois P., Fruchart J.C., Staels B., Induction of IkBa expression as a mechanism contributing to the anti-inflammatory activities of PPARa activators, J. Biol. Chem., 275, pp. 36703-36707, (2000)
[26] Delerive P., De Bosscher K., Vanden Berghe W., Et al., DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha, Mol. Endocrinol., 16, pp. 1029-1039, (2002)
[27] Kleemann R., Gervois P.P., Verschuren L., Et al., Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NF{kappa}B ∼C/EBP- {beta} complex formation, Blood, 101, pp. 545-551, (2002)
[28] Gervois P., Vu-Dac N., Kleemann R., Et al., Negative regulation of human fibrinogen gene expression by PPAR{alpha} agonists via inhibition of C/EBPbeta, J. Biol. Chem., 276, pp. 33471-33477, (2001)
[29] Gervois P., Kleemann R., Pilon A., Et al., Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate, J. Biol. Chem., 279, pp. 16154-16160, (2004)
[30] Chinetti G., Fruchart J.C., Staels B., Peroxisome proliferator-activated receptors and inflammation: From basic science to clinical applications, Int. J. Obes. Relat. Metab. Disord., 27, SUPPL. 3, (2003)

← 1 2 3 4 5 6 →