Impact of body weight and weight loss on cardiovascular risk factors

被引:13
作者
Hecker K.D. [1 ]
Kris-Etherton P.M. [1 ]
Zhao G. [1 ]
Coval S. [1 ]
St. Jeor S. [2 ]
机构
[1] Nutrition Department, The Pennsylvania State University, 126 South Henderson, University Park, 16802, PA
[2] Nutrition Education and Research Program, University of Nevada School of Medicine, 155 Redfield Building, Reno, 89557, NV
关键词
Improve Plasma Lipid; Lipoprotein Profile; National Cholesterol Education Program; Plasma Lipoprotein Profile; Weight Loss Group;
D O I
10.1007/s11883-999-0038-2
中图分类号
学科分类号
摘要
Overwieght and obesity are classified as a major risk for cardiovascular disease (CVD). An increase in the body mass index is associated with adverse changes in the plasma lipid and lipoprotein profile resulting in elevated total cholesterol, low-density lipoprotein-cholesterol, and triglyceride levels and a decrease in high-density lipoprotein levels. An android pattern of obesity is associated with a more deleterious plasma lipoprotein profile as well as hypertension and insulin resistance, resulting in an even greater increase in CVD risk. Weight loss through caloric restriction improves the plasma lipoprotein profile. A Step-1 diet plus exercise confer even greater benefits. © 1999, Current Science Inc.
引用
收藏
页码:236 / 242
页数:6
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共 62 条
[11]  
Walton C., Lees B., Crook D., Et al., Body fat distribution, rather than overall adiposity influences serum lipids and lipoproteins in healthy men independently of age, Am J Med, 99, pp. 450-464, (1995)
[12]  
Katzel L.I., Busby-Whitehead J.M., Goldberg A.P., Adverse effects of abdominal obesity on lipoprotein lipids in healthy older men, Exp Gerontol, 28, pp. 411-420, (1993)
[13]  
Katzel L.I., Coon P.J., Rogus E., Et al., Persistence of low HDL-C levels after weight reduction in older men with small LDL particles, Arterioscler Thromb Vasc Biol, 15, pp. 299-305, (1995)
[14]  
Despres J.-P., Moorjani S., Ferland M., Et al., Adipose tissu distribution and plasma lipoprotein levels in obese women: importance of intra-abdominal fat, Arteriosclerosis, 9, pp. 203-210, (1989)
[15]  
Dattilo A.M., Kris-Etherton P.M., Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis, Am J Clin Nutr, 56, pp. 320-328, (1992)
[16]  
Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults, Arch Intern Med, 148, pp. 36-39, (1988)
[17]  
Second report of the expert panel on detection, evaluation, And Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II), (1993)
[18]  
Pietrobelli A., Lee R.C., Capristo E., Et al., An independent, inverse association of high-density-lipoprotein-cholesterol concentration with nonadipose body mass, Am J Clin Nutr, 69, pp. 614-620, (1999)
[19]  
Denke M.A., Sempos C.T., Grundy S.M., Excess body weight. An underrecognized contributor to dyslipidemia in whit American women, Arch Intern Med, 154, pp. 401-410, (1994)
[20]  
Law M.R., Wald N.J., Thompson S.G., By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischemic heart disease?, Br Med J, 308, pp. 367-773, (1994)