Update on inflammatory bowel disease genetics.

被引：11

作者：

Cho J. ^{[1
]}

机构：

[1] The Martin Boyer Laboratories, The University of Chicago, 5841 South Maryland Avenue, Chicago, 60637, IL

来源：

Current Gastroenterology Reports | 2000年 / 2卷 / 6期

关键词：

Inflammatory Bowel Disease; Ulcerative Colitis; Risk Allele; Cerebral Malaria; Human Genomic Sequence;

D O I：

10.1007/s11894-000-0004-1

中图分类号：

学科分类号：

摘要：

The idiopathic inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are related, complex genetic disorders. With the completion of the human genomic sequence, identification of genetic variants contributing to IBD susceptibility can now more systematically be identified. Significant genetic linkages have been observed on chromosomes 16, 12, 14, 19, 6, and 1, of which the linkage to CD on chromosome 16 is the most well-established. For many of the other regions, evidence for linkage has been observed for both CD and UC. Candidate gene association studies have largely focused on genes involved in inflammatory pathways, such as cytokines and cytokine receptors. With greater understanding of genetic differences underlying both disease susceptibility and response to medical therapy, the individualization of medical approaches based on this knowledge may soon be possible in patients with IBD.

引用

页码：434 / 439

页数：5

共 130 条

[41] Field TS(2000)Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease Gastroenterology 118 274-278
[42] Holtzman NA(2000)Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease Gastroenterology 118 705-713
[43] Marteau TM(1999)Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine Br J Pharmacol 128 1361-1369
[44] Altshuler D(2000)Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with p-glycoprotein expression and activity in vivo Proc Natl Acad Sci U S A 97 3473-3478
[45] Hirschhorn JN(2000)High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy Gastroenterology 118 279-288
[46] Klannemark M(1999)Molecular classification of cancer: class discovery and class prediction by gene expression monitoring Science 286 531-537
[47] Podolsky DK(2000)Ulcerative colitis and Crohn's disease tissue gene expression profiling by DNA microarrays: diagnostic and therapeutic implications [abstract] Gastroenterology 118 A1872-A1872
[48] Rath HC(undefined)undefined undefined undefined undefined-undefined
[49] Herfarth HH(undefined)undefined undefined undefined undefined-undefined
[50] Ikeda JS(undefined)undefined undefined undefined undefined-undefined

← 1 2 3 4 5 6 7 8 9 10 →