MRI Phenotype Is Associated With Response to Doxorubicin and Cyclophosphamide Neoadjuvant Chemotherapy in Stage III Breast Cancer

被引:21
作者
Laura Esserman
Elizabeth Kaplan
Savanah Partridge
Debasish Tripathy
Hope Rugo
John Park
Shelley Hwang
Henry Kuerer
Dan Sudilovsky
Ying Lu
Nola Hylton
机构
[1] University of California,Department of Surgery
[2] University of California,Department of Bioengineering
[3] University of California,Department of Pathology
[4] University of California,Department of Radiology
[5] University of California,Department of Medicine
关键词
Magnetic resonance imaging; Neoadjuvant chemotherapy; Locally advanced breast cancer;
D O I
10.1007/s10434-001-0549-8
中图分类号
学科分类号
摘要
Background: The preferred management for women with stage II or locally advanced breast cancer (LABC) is neoadjuvant chemotherapy. Pathologic response to chemotherapy has been shown to be an excellent predictor of outcome. Surrogates that can predict pathologic response and outcome will fuel future changes in management. Magnetic resonance imaging (MRI) demonstrates that patients with LABC have distinct tumor patterns. We investigated whether or not these patterns predict response to therapy.
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页码:549 / 559
页数:10
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共 119 条
[1]  
Hillner BE(1991)Efficacy and cost effectiveness of adjuvant chemotherapy in women with node-negative breast cancer. A decision-analysis model N Engl J Med 324 160-168
[2]  
Smith TJ(1986)MR imaging of the breast using gadolinium-DTPA J Comput Assist Tomogr 10 199-204
[3]  
Heywang SH(1989)MR imaging of the breast: fast imaging sequences with and without Gd-DTPA. Preliminary observations Radiology 170 681-686
[4]  
Hahn D(1989)MR imaging of the breast with Gd-DTPA: use and limitations Radiology 171 95-103
[5]  
Schmidt H(1986)Gd-DTPA contrast enhancement and tissue differentiation in MR imaging of experimental breast carcinoma Radiology 158 319-323
[6]  
Kaiser WA(1991)Three-dimensional gadolinium-enhanced MR imaging of the breast: pulse sequence with fat suppression and magnetization transfer contrast. Work in progress Radiology 181 757-763
[7]  
Zeitler E(1990)Breast disease: tissue characterization with Gd-DTPA enhancement profiles Radiology 174 491-494
[8]  
Heywang SH(1993)MR imaging of the breast with rotating delivery of excitation off resonance: clinical experience with pathologic correlation Radiology 187 493-501
[9]  
Wolf A(1994)Suspicious breast lesions: MR imaging with radiologic-pathologic correlation Radiology 190 485-493
[10]  
Pruss E(1992)Contrast-enhanced magnetic resonance imaging of the breast Acta Oncol 31 833-842