MRI Phenotype Is Associated With Response to Doxorubicin and Cyclophosphamide Neoadjuvant Chemotherapy in Stage III Breast Cancer

被引:21
作者
Laura Esserman
Elizabeth Kaplan
Savanah Partridge
Debasish Tripathy
Hope Rugo
John Park
Shelley Hwang
Henry Kuerer
Dan Sudilovsky
Ying Lu
Nola Hylton
机构
[1] University of California,Department of Surgery
[2] University of California,Department of Bioengineering
[3] University of California,Department of Pathology
[4] University of California,Department of Radiology
[5] University of California,Department of Medicine
关键词
Magnetic resonance imaging; Neoadjuvant chemotherapy; Locally advanced breast cancer;
D O I
10.1007/s10434-001-0549-8
中图分类号
学科分类号
摘要
Background: The preferred management for women with stage II or locally advanced breast cancer (LABC) is neoadjuvant chemotherapy. Pathologic response to chemotherapy has been shown to be an excellent predictor of outcome. Surrogates that can predict pathologic response and outcome will fuel future changes in management. Magnetic resonance imaging (MRI) demonstrates that patients with LABC have distinct tumor patterns. We investigated whether or not these patterns predict response to therapy.
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页码:549 / 559
页数:10
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