Antiretrovirals to prevent HIV infection: Pre- and postexposure prophylaxis

被引：17

作者：

Gay C.L. ^{[1
]}

Cohen M.S. ^{[1
]}

机构：

[1] Division of Infectious Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

来源：

Current Infectious Disease Reports | 2008年 / 10卷 / 4期

基金：

美国国家卫生研究院;

关键词：

Tenofovir; Tenofovir Disoproxil Fumarate; Emtricitabine; Maraviroc; Serodiscordant Couple;

D O I：

10.1007/s11908-008-0052-5

中图分类号：

学科分类号：

摘要：

More than 3 million people are now receiving antiretroviral therapy (ART) worldwide. Currently, the indications for ART depend primarily on CD4 count, blood viral burden, and clinical signs and symptoms suggesting advanced HIV disease. However, interest is increasing in ART's preventive potential. Postexposure prophylaxis following both occupational and nonoccupational exposure to HIV is the standard-of-care in many settings. Observational and ecologic studies suggest that ART administered to HIV-infected people reduces transmission within serodiscordant couples. Pre-exposure prophylaxis to prevent HIV infection is a potentially safe and intermittent intervention for very high-risk people, and clinical trials to evaluate this preventive strategy are underway. The prevention benefits of ART may begin to affect the decision of when to start therapy and add a much-needed strategy to current HIV prevention efforts. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：323 / 331

页数：8

共 77 条

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