The metabolic syndrome in children and adolescents

被引:201
作者
Cruz M.L. [1 ]
Goran M.I. [1 ]
机构
[1] Dept. of Prev. Medicine/Physiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089
基金
美国国家卫生研究院;
关键词
Insulin Resistance; Metabolic Syndrome; Impaired Glucose Tolerance; Impaired Fasting Glucose; National Cholesterol Education Program;
D O I
10.1007/s11892-004-0012-x
中图分类号
学科分类号
摘要
The metabolic syndrome was recently defined by the Adult Treatment Panel III. Despite a lack of uniform definition of the syndrome in pediatrics, recent studies have shown that the syndrome develops during, childhood and is highly prevalent among overweight children and adolescents. The hypothesized central role of insulin resistance and obesity as a common underlying feature of the metabolic syndrome also appears to be already manifested in childhood. In view of the current obesity epidemic in children and adolescents, there is a vital need to provide adequate guidelines for the definition of the metabolic syndrome in pediatrics and for the development of screening and treatment strategies. This article focuses on the above issues, as well as on the impact of the syndrome on two major disease outcomes, type 2 diabetes and cardiovascular disease. Copyright © 2004 by Current Science Inc.
引用
收藏
页码:53 / 62
页数:9
相关论文
共 57 条
[1]  
Alexander C.M., Landsman P.B., Teutsch S.M., Haffner S.M., NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older, Diabetes, 52, pp. 1210-1214, (2003)
[2]  
Ford E.S., Giles W.H., Dietz W.H., Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey, JAMA, 287, pp. 356-359, (2002)
[3]  
Meigs J.B., Wilson P.W., Nathan D.M., Et al., Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies, Diabetes, 52, pp. 2160-2167, (2003)
[4]  
Isomaa B., Almgren P., Tuomi T., Et al., Cardiovascular morbidity and mortality associated with the metabolic syndrome, Diabetes Care, 24, pp. 683-689, (2001)
[5]  
Lakka H.M., Laaksonen D.E., Lakka T.A., Et al., The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men, JAMA, 288, pp. 2709-2716, (2002)
[6]  
Laaksonen D.E., Lakka H.M., Niskanen L.K., Et al., Metabolic syndrome and development of diabetes mellitus: Application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study, Am. J. Epidemiol., 156, pp. 1070-1077, (2002)
[7]  
Hanson R.L., Imperatore G., Bennett P.H., Knowler W.C., Components of the "metabolic syndrome" and incidence of type 2 diabetes, Diabetes, 51, pp. 3120-3127, (2002)
[8]  
Cook S., Weitzman M., Auinger P., Et al., Prevalence of a metabolic syndrome phenotype in adolescents: Findings from the third National Health and Nutrition Examination Survey, 1988-1994, Arch. Pediatr. Adolesc. Med., 157, pp. 821-827, (2003)
[9]  
Chen W., Srinivasan S.R., Elkasabany A., Berenson G.S., Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black-White) population of children, adolescents, and young adults: The Bogalusa Heart Study, Am. J. Epidemiol., 150, pp. 667-674, (1999)
[10]  
Chen W., Bao W., Begum S., Et al., Age-related patterns of the clustering of cardiovascular risk variables of syndrome X from childhood to young adulthood in a population made up of black and white subjects: The Bogalusa Heart Study, Diabetes, 49, pp. 1042-1048, (2000)