Adherence to antihypertensive medications: A review and update

被引：6

作者：

Costa F.V. ^{[1
]}

D'Ausilio A. ^{[2
]}

Bianchi C. ^{[3
]}

Negrini C. ^{[2
]}

Lopatriello S. ^{[4
]}

机构：

[1] Department of Internal Medicine, University of Bologna, Bologna

[2] PBE Consulting, Milan

[3] Department of Health Economics, Outcome, Pricing and Reimbursement, Bayer Schering Pharma-Viale Certosa

[4] PBE Consulting, Verona

来源：

High Blood Pressure & Cardiovascular Prevention | 2009年 / 16卷 / 3期

关键词：

Adherence to treatment; Antihypertensive drugs; Compliance to treatment; Cost of non-compliance; Treatment discontinuation;

D O I：

10.2165/11530330-000000000-00000

中图分类号：

学科分类号：

摘要：

The aim of this review was to summarize recent findings on patients adherence and persistence to antihypertensive (AHT) therapy. A literature search was performed using MEDLINE for original studies published in the English language between April 2003 and July 2008. According to selection criteria, the review included 47 papers classified into the following groups: (i) studies assessing overall behaviour towards treatment; (ii) studies differentiating among AHT classes; and (iii) studies comparing specific AHTs. It was not possible to perform a meta-analysis due to the wide variety of study designs, objectives and definitions. However, some strong messages emerged: non-adherent patients have higher blood pressure (BP) values, which lead to a higher risk of cardiovascular events; angiotensin II type 1 receptor antagonists (angiotensin receptor blockers) are the AHTs with the best patient adherence and persistence to treatment; better treatment adherence is observed in patients using fixed versus extemporaneous AHT combinations. Improving BP control is pivotal to reduce cardiovascular events, allowing for a better use of healthcare resources, and good adherence and persistence to treatment are essential for reaching this goal. © 2009 Adis Data Information BV. All rights reserved.

引用

页码：101 / 110

页数：9

共 67 条

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[20]

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