Regulation of allergic airways inflammation by cytokines and glucocorticoids

被引：7

作者：

Cameron L. ^{[1
]}

Hamid Q. ^{[2
]}

机构：

[1] Respiratory Sciences Center, University of Arizona, Tucson, AZ

[2] Meakins-Christie Laboratories, McGill University, H2X 2P2, Montreal, PQ, QC

来源：

Current Allergy and Asthma Reports | 2001年 / 1卷 / 2期

关键词：

Asthma; Mast Cell; Allergic Rhinitis; Fluticasone Propionate; Allergy Clin Immunol;

D O I：

10.1007/s11882-001-0083-6

中图分类号：

学科分类号：

摘要：

Cytokines mediate the allergic inflammatory response of the airways, and glucocorticosteroids ameliorate allergy symptoms by regulating cytokine expression. Recent studies provide insight into the manner by which cytokines work together to mediate allergic airway disease. Real progress has also been gained in our understanding of subcellular mechanisms of allergic inflammation, particularly the role of transcription factors in regulating the expression of specific cytokine profiles and the differentiation of the TH2 subset. This article provides an update of recently reported findings in this field and highlights emerging concepts of allergic inflammation.

引用

页码：153 / 163

页数：10

共 170 条

[81]

Thornhill MH, Wellicome SM, Mahiouz DL, Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells: the contribution of vascular cell adhesion molecule-1-dependent and-independent binding mechanisms, J Immunol, 146, pp. 592-598, (1991)

[82]

Schall TJ, Jongstra J, Dyer BJ, A human T cell-specific molecule is a member of a new gene family, J Immunol, 141, pp. 1018-1025, (1988)

[83]

Garcia-Zepeda EA, Combadiere C, Rothenberg ME, Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3, J Immunol, 157, pp. 5613-5626, (1996)

[84]

Kuna P, Alam R, Ruta U, Gorski P, RANTES induces nasal mucosal inflammation rich in eosinophils, basophils, and lymphocytes in vivo, Am J Respir Crit Care Med, 157, pp. 873-879, (1998)

[85]

Center DM, Kornfeld H, Cruikshank WW, Interleukin 16 and its function as a CD4 ligand, Immunol Today, 17, pp. 476-481, (1996)

[86]

Stellato C, Beck LA, Gorgone GA, Expression of the chemokine RANTES by a human bronchial epithelial cell line: modulation by cytokines and glucocorticoids, J Immunol, 155, pp. 410-418, (1995)

[87]

Li L, Xia Y, Nguyen A, Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells, J Immunol, 162, pp. 2477-2487, (1999)

[88]

Bochner BS, Road signs guiding leukocytes along the inflammation superhighway, J Allergy Clin Immunol, 106, pp. 817-828, (2000)

[89]

Luster AD, Chemokines—chemotactic cytokines that mediate inflammation, N Engl J Med, 338, pp. 436-445, (1998)

[90]

Laberge S, Ernst P, Ghaffar O, Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma, Am J Respir Cell Mol Biol, 17, pp. 193-202, (1997)

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