Weighing the evidence for infection as a risk factor for coronary heart disease

被引：12

作者：

O'Donnell C.J. ^{[1
]}

Levy D. ^{[1
]}

机构：

[1] Framingham Heart Study, Framingham, MA 01702

来源：

Current Cardiology Reports | 2000年 / 2卷 / 4期

关键词：

Coronary Heart Disease; Azithromycin; Coronary Heart Disease Risk; Traditional Risk Factor; Roxithromycin;

D O I：

10.1007/s11886-000-0082-6

中图分类号：

学科分类号：

摘要：

There has been considerable attention in recent years to the intriguing hypothesis that coronary heart disease and other atherosclerotic diseases may be caused by infection with pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus. Supporting this hypothesis are studies that localize bacterial antigens to atherosclerotic plaques and that draw associations of systemic inflammation and chronic infections with coronary disease. Although there are several examples of positive associations of pathogen seropositivity with disease, recent prospective follow-up studies of infection seropositivity have not generally supported these associations. At present, the evidence is insufficient to designate infection as a causal risk factor for coronary heart disease. The results of ongoing larger observational studies and antibiotic treatment trials may yield important information regarding the presence and magnitude of risk, if any, beyond that conferred by established coronary risk factors. Copyright © 2000 by Current Science Inc.

引用

页码：280 / 287

页数：7

共 47 条

[21]

Kannel W.B., Anderson K., Wilson P.W., White blood cell count and cardiovascular disease. Insights from the Framingham Study, JAMA, 267, pp. 1253-1256, (1992)

[22]

Ridker P.M., Cushman M., Stampfer M.J., Et al., Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men, N Engl J Med, 336, pp. 973-979, (1997)

[23]

Wilson P.W.F., D'Agostino R.B., Levy D., Et al., Prediction of coronary heart disease using risk factor categories, Circulation, 97, pp. 1837-1847, (1998)

[24]

O'Donnell C.J., Larson M.G., Benjamin E., Et al., Relationship of C-reactive protein to coronary and aortic calcification in the Framingham Heart Study [abstract], Circulation, 101, pp. 713-714, (2000)

[25]

Haider A.W., Larson M.G., O'Donnell C.J., Et al., The association of chronic cough with the risk of myocardial infarction: The Framingham Heart Study, Am J Med, 106, pp. 279-284, (2000)

[26]

Beck J.D., Offenbacher S., Williams R., Gibbs P., Garcia R., Periodontitis: A risk factor for coronary heart disease, Ann Periodontol, 3, pp. 127-141, (1998)

[27]

Christen W.G., Hennekens C.H., Ajani U.A., Et al., Periodontal disease and risks of cardiovascular disease [abstract], Circulation, 97, (1998)

[28]

Zhu J., Quyyumi A.A., Norman J.E., Et al., Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels, Am J Cardiol, 85, pp. 140-146, (2000)

[29]

Ossewaarde J.M., Feskens E.J., De Vries A., Et al., Chlamydia pneumoniae is a risk factor for coronary heart disease in symptom-free elderly men, but Helicobacter pylori and cytomegalovirus are not, Epidemiol Infect, 120, pp. 93-99, (1998)

[30]

Roivainen M., Viik-Kajander M., Palosuo T., Et al., Infections, inflammation, and the risk of coronary heart disease, Circulation, 101, pp. 252-257, (2000)

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