Contemporary management of refractory hypertension

被引：12

作者：

Alper Jr. A.B. ^{[1
]}

Calhoun D.A. ^{[1
]}

机构：

[1] Address Vascular Biology and Hypertension Program, University of Alabama, Birmingham, AL 35242

来源：

Current Hypertension Reports | 1999年 / 1卷 / 5期

关键词：

Obstructive Sleep Apnea; Sleep Apnea; Resistant Hypertension; Home Blood Pressure; Contemporary Management;

D O I：

10.1007/s11906-999-0055-0

中图分类号：

学科分类号：

摘要：

Refractory or resistant hypertension is conventionally defined as systolic or diastolic blood pressure that remains uncontrolled despite sustained therapy with at least three different classes of antihypertensive agents. Refractory hypertension is estimated to affect less than 5% of the general population with hypertension; however, its prevalence increases with increasing severity of blood pressure. Patients presenting with refractory hypertension usually have progressed from mild, to moderate, to severe hypertension because of lack of or inadequate treatment. Other common contributing factors include obesity, medical nonadherence, suboptimal medical regimens, excessive dietary salt ingestion, secondary forms of hypertension, sleep apnea, and ingestion of substances that interfere with treatment. Combination therapy that includes appropriate doses of a diuretic is recommended for treatment of refractory hypertension. Use of fixed-dose combinations enhances compliance through cost savings, more convenient dosing, and reduced pill burdens. Copyright © 1999 by Current Science, Inc.

引用

页码：402 / 407

页数：5

共 22 条

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