Mechanisms of the Effects of Adrenocorticotropic Hormone on Pain Sensitivity in Rats

被引：10

作者：

A. I. Bogdanov

N. I. Yarushkina

机构：

[1] Department of Endocrine Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences

来源：

Neuroscience and Behavioral Physiology | 2003年 / 33卷 / 8期

关键词：

ACTH; Corticosterone; Opiate receptors; Pain sensitivity; Rats;

D O I：

10.1023/A:1025149432058

中图分类号：

学科分类号：

摘要：

Experiments on anaesthetized male Sprague-Dawley rats were performed to study the effects of adrenocorticotropic hormone (ACTH) on pain sensitivity. Systemic administration of ACTH to animals with normal hormone production induced rapidly developing (starting at 3 min) and prolonged (30 min) increases in pain response thresholds. Blockade of opiate receptors led to suppression of the initial stage of the analgesic effect of ACTH: the response was seen only from 15 to 30 min. In animals with deficient glucocorticoid production, the duration of the analgesic action of ACTH decreased to 15 min. Analgesia was completely eliminated by the combination of suppression of glucocorticoid production and blockade of opiate receptors. The analgesic effect of ACTH was mediated by two mechanisms: 1) a rapidly-acting (from 3 to 15 min) mechanism associated with opiate receptors and not related to glucocorticoids, and 2) a delayed (from 15 to 30 min) mechanism associated with glucocorticoids but not opiate receptors.

引用

页码：795 / 798

页数：3

共 19 条

[11]

Lariviere W.R., Melzack R., The role of corticotropin-releasing factor in pain and analgesia, Pain, 84, 1, pp. 1-12

[12]

Lewis J.W., Cannon J.T., Liebeskind J.C., Opioid and non-opioid mechanisms of stress-induced analgesia, Science, 208, pp. 623-625, (1980)

[13]

Maier S.F., Stressor controllability and stress-induced analgesia, Ann. N.Y. Acad. Sci., 467, pp. 55-72, (1986)

[14]

Sadowski B., Difference in escaping electric footshock by genetic mouse lines selectively bred for divergent levels of swim-induced analgesia, Acta Neurobiol. Exp., 48, 1, pp. 1-7, (1988)

[15]

Sutton L.C., Fleshner M., Mazzeo R., Maier S.F., Watkins L.R., A permissive role of corticosterone in an opioid form of stress-induced analgesia: Blockade of opiate analgesia is not due to stress-induced hormone release, Brain Res., 663, 1, pp. 19-29, (1994)

[16]

Takeshige C., Tsuchiya M., Zhao W., Guo S., Analgesia produced by pituitary ACTH and dopaminergic transmission in the arcuate, Brain Res. Bull., 256, 5, pp. 779-788, (1991)

[17]

Tierney G., Carmondy J., Jamieson D., Stress-analgesia: The opioid analgesia of long swims suppresses the non-opioid analgesia induced by short swims in mice, Pain, 46, pp. 89-95, (1991)

[18]

Xi-Cheng L., Hai-Di L., Bang-Yun Z., Serotonin of hippocampus and hypothalamus taking part in the analgesic effect of adrenocorticotropic hormone in rats, Acta Pharmacol. Sin., 11, 1, pp. 89-92, (1990)

[19]

Xi H.W., Li X.C., Li H.D., Ruan H.Z., Liu Z.Z., Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain, Acta Pharmacol. Sin., 21, 7, pp. 600-604, (2000)

← 1 2 →