Body mass index as a predictor of continued survival in older chronic dialysis patients

被引：34

作者：

Kutner N.G. ^{[1
]}

Zhang R. ^{[2
]}

机构：

[1] Department of Rehabilitation Medicine, Emory University, School of Medicine, Atlanta, GA 30322

[2] Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA

来源：

International Urology and Nephrology | 2001年 / 32卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Aging; Body mass index; Dialysis; Mortality; Nutrition; Race;

D O I：

10.1023/A:1017581726362

中图分类号：

学科分类号：

摘要：

Objective: To investigate the contribution of body mass index (BMI) to mortality over 11 years of follow-up in a prevalent sample of dialysis patients aged 60+. Design: Multivariate Cox proportional hazards regression analysis. Setting: Multicenter stratified random sample of black and white older chronic dialysis patients in a southeastern state. Subjects: 316 patients on hemodialysis (HD) and peritoneal dialysis (PD). Main outcome measure: Continued survival from baseline interview in 1988 to June 1999. Results: Adjusting for age, primary diagnosis of diabetes, cardiovascular comorbidity, HD/PD therapy, and patient-reported functional impairment, the interaction of baseline BMI with race and gender was associated with older patients' risk of mortality. Black females, black males, and white males with higher BMI had a reduced risk of mortality, while no protective effect of higher BMI was found for white females. Patients with cardiovascular comorbidity and greater functional impairment at baseline had increased mortality risk. BMI was not significantly correlated with serum albumin or functional impairment. Conclusion: BMI, a simple anthropometric measure that provides a marker of nutritional status, interacts with race and gender to predict long-term survival in older dialysis patients. The association of survival with dialysis adequacy, nutritional indicators, and cardiovascular status in black and white dialysis patients is an important area of study.

引用

页码：441 / 448

页数：7

共 32 条

[11] Lorenzo V., De Bonis E., Rufino M., Et al., Caloric rather than protein deficiency predominates in stable chronic haemodialysis patients, Nephrol Dial Transplant, 10, pp. 1885-1859, (1995)
[12] Hiroshige K., Kabashima N., Kanegae K., Et al., Dialysis efficacy and nutritional status in elderly hemodialyzed patients, Geriatr Nephrol Urol, 6, pp. 149-158, (1997)
[13] Kutner N.G., Brogan D., Fielding B., Hall W.D., Older renal dialysis patients and quality of life, Dial Transplant, 20, pp. 171-175, (1991)
[14] House J.S., Americans' Changing Lives: Wave I [MRDF], (1986)
[15] Garfein A.J., Herzog A.R., Robust aging among the young old, old-old, and oldest-old, J Gerontol Soc Sci, 50 B, (1995)
[16] Kutner N.G., Lin L.S., Fielding B., Et al., Continued survival of older hemodialysis patients: Investigation of psychosocial predictors, Am J Kidney Dis, 24, pp. 42-49, (1994)
[17] Brogan D., Kutner N.G., Flagg E., Survival differences among older dialysis patients in the Southeast, Am J Kidney Dis, 20, pp. 376-386, (1992)
[18] Cox D.R., Oakes D., Analysis of Survival Data, (1984)
[19] SAS Version 6.12, (1990)
[20] Kopple J.D., Zhu X., Lew N.L., Lowrie E.G., Body weight-for-height relationships predict mortality in maintenance hemodialysis patients, Kidney Int, 56, pp. 1136-1148, (1999)

← 1 2 3 4 →