Oxidative stress and vascular damage in hypertension

被引：160

作者：

Touyz R.M. ^{[1
]}

机构：

[1] MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, Montreal, QC H2W 1R7

来源：

Current Hypertension Reports | 2000年 / 2卷 / 1期

关键词：

Reactive Oxygen Species; Vascular Smooth Muscle Cell; NADPH Oxidase; Vascular Damage; Human Vascular Smooth Muscle Cell;

D O I：

10.1007/s11906-000-0066-3

中图分类号：

学科分类号：

摘要：

Metabolism of oxygen by cells generates potentially deleterious reactive oxygen species, including superoxide anion radical, hydrogen peroxide, and hydroxyl radical. Under normal physiologic conditions the rate and magnitude o oxidant formation is balanced by the rate of oxidant elimination. However, an imbalance between prooxidants and antioxidants results in oxidative stress, which is the pathogenic outcome of the overproduction of oxidants that overwhelms the cellular antioxidant capacity. There is increasing evidence that an elevation of oxidative stress and associated oxidative damages are mediators of vascular injury in various cardiovascular pathologies, including hypertension, atherosclerosis, and ischemia-reperfusion. This review focuses on the vascular effects of reactive oxygen species and the role of oxidative stress in vascular damage in hypertension. Copyright © 2000 by Current Science Inc.

引用

页码：98 / 105

页数：7

共 53 条

[41] White B.H., Sidhu A., Increased oxidative stress in renal proximal tubules of the SHR: A mechanism for defective dopamine D1A receptor/G - Protein coupling, J Hypertens, 16, pp. 1659-1665, (1998)
[42] Negishi H., Ikeda K., Sagara M., Sawamura Y., Increased oxidative DNA damage in stroke-prone SHR, Clin Exp Pharmacol Physiol, 26, pp. 482-484, (1999)
[43] Singh R.B., Niaz M.A., Rastogi S.S., Et al., Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease, J Hum Hypertens, 13, pp. 203-208, (1999)
[44] Koska J., Syrova D., Blazicek P., Et al., Malondialdehyde, lipo-fuscin and activity of antioxidant enzymes during physical exercise in patients with essential hypertension, J Hypertens, 17, pp. 529-535, (1999)
[45] Akpaffiong M.J., Taylor A.A., Antihypertensive and vasodilator actions of antioxidants in SHR, Am J Hypertens, 11, pp. 1450-1460, (1998)
[46] Nunes G.L., Sgoutas D.S., Redden R.A., Combination of vitamins C and E alters the response to coronary balloon injury in the pig, Arterioscler Thromb Vasc Biol, 15, pp. 156-165, (1995)
[47] Nakazono K., Watanabe N., Matsuno S., Et al., Does superoxide underlie the pathogenesis of hypertension?, Proc Natl Acad Sci USA, 88, pp. 10045-10048, (1991)
[48] Tschudi M., Mesaros S., Luscher T.F., Malinski T., Direct in situ measurement of nitric oxide in mesenteric resistance arteries: Increased decomposition by superoxide in hypertension, Hypertension, 27, pp. 32-35, (1996)
[49] Kurose I., Wolf R., Cerwinka W., Granger D.N., Microvascular responss to ischemia/reperfusion in normotensive and hypertensive rats, Hypertension, 34, pp. 212-216, (1999)
[50] Kristal B., Shurtz-Swirrski R., Chezar J., Et al., Participation of peripheral polymorphonuclear leukocytes in the oxidative stress and inflammation in patients with essential hypertension, Am J Hypertens, 11, pp. 921-928, (1998)

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