Molecular analysis of pediatric brain tumors

被引：16

作者：

Biegel J.A. ^{[1
]}

Pollack I.F. ^{[1
]}

机构：

[1] Division of Human Genetics, Department of Pediatrics, Univ. of Pennsylvania Sch. Medicine, Philadelphia, PA 19104

来源：

Current Oncology Reports | 2004年 / 6卷 / 6期

基金：

美国国家卫生研究院;

关键词：

Astrocytoma; Medulloblastoma; Malignant Glioma; Pilocytic Astrocytoma; Epidermal Growth Factor Receptor Gene;

D O I：

10.1007/s11912-004-0075-5

中图分类号：

学科分类号：

摘要：

The identification of molecular genetic abnormalities in specific types of pediatric brain tumors is beginning to play a role in the stratification of patients into treatment groups. The finding of an INI 1 alteration in an atypical teratoid/ rhabdoid tumor or malignant neoplasm with overlapping histologic features will be required for entry onto diseasespecific protocols within the Children's Oncology Group. Refinement in the classification of medulloblastoma and malignant glioma patients will likely depend on the genetic and signaling pathways that characterize these tumors. Advances in this area will depend on the ability to identify new disease genes, validate prognostic markers, and develop biologically based therapeutic strategies to tailor treatment. Copyright © 2004 by Current Science Inc.

引用

页码：445 / 452

页数：7

共 80 条

[31]

Waha A., Koch A., Hartmann W., Et al., Analysis of HIC-1 methylation and transcription in human ependymomas, Int. J. Cancer, 110, pp. 542-549, (2004)

[32]

von Deimling A., Louis D.N., Menon A.G., Et al., Deletions on the long arm of chromosome 17 in pilocytic astrocytoma, Acta Neuropathol., 86, pp. 81-85, (1993)

[33]

Guttmann D.H., Donahoe J., Brown T., Et al., Loss of neurofibromatosis 1(NF1) gene expression in NF1-associated pilocytic astrocytomas, Neuropathol. Appl. Biol., 26, pp. 361-367, (2000)

[34]

Griffin C.A., Hawkins A.L., Packer R.J., Et al., Chromosome abnormalities in pediatric brain tumors, Cancer Res., 48, pp. 175-180, (1988)

[35]

Karnes P.S., Tran T.N., Cui M.Y., Et al., Cytogenetic analysis of 39 pediatric central nervous system tumors, Cancer Genet. Cytogenet., 59, pp. 12-19, (1992)

[36]

Lang F.F., Miller D.C., Koslow M., Et al., Pathways leading to glioblastoma multiforme: A molecular analysis of genetic alterations in 65 astrocytic tumors, J. Neurosurg., 81, pp. 427-436, (1994)

[37]

Litofsky N.S., Hinton D., Raffel C., The lack of a role for p53 in astrocytomas in pediatric patients, Neurosurgery, 34, pp. 967-973, (1994)

[38]

James C.D., Carlbom E., Nordenskjold M., Et al., Mitotic recombination of chromosome 17 in astrocytomas, Proc. Natl. Acad. Sci. U S A, 86, pp. 2858-2862, (1989)

[39]

Lang F.F., Miller D.C., Pisharody S., Et al., High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas, Oncogene, 9, pp. 949-954, (1994)

[40]

Cheng Y., Pang J.C., Ng H.K., Et al., Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas, Histopathology, 37, pp. 437-444, (2000)

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