An association between asthma and TNF-308G/A polymorphism: Meta-analysis

被引：56

作者：

Aoki T. ^{[1
]}

Hirota T. ^{[2
]}

Tamari M. ^{[2
]}

Ichikawa K. ^{[1
]}

Takeda K. ^{[3
]}

Arinami T. ^{[4
]}

Shibasaki M. ^{[5
]}

Noguchi E. ^{[4
]}

机构：

[1] Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba

[2] Laboratory of Genetics of Allergic Diseases, RIKEN SNP Research Center, Yokohama

[3] Institute of Disability Sciences, Tsukuba

[4] Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8577

[5] Department of Pediatrics, Tsukuba College of Technology, Tsukuba

来源：

Journal of Human Genetics | 2006年 / 51卷 / 8期

关键词：

Asthma; Case-control; Meta-analysis; Polymorphism; TDT; TNF;

D O I：

10.1007/s10038-006-0007-3

中图分类号：

学科分类号：

摘要：

Tumor necrosis factor (TNF) is a potent inflammatory cytokine that contributes to airway inflammation in asthma. Previous studies have reported that a G-to-A transition at position -308 (-308G/A, also referred to as TNF-α-308*1 and 308*2 respectively), is associated with asthma, but other studies have shown conflicting results. To investigate a possible association between the TNF-308G/A polymorphism and asthma, we performed transmission disequilibrium tests and a case-control study (family samples: 495 members in 165 Japanese trio families with one asthmatic child and both parents; case-control samples: 461 Japanese asthmatic children and 465 healthy controls). To increase the sample size and power, we performed a meta-analysis of all available relevant studies, including 2,477 asthmatics and 3,217 controls. We did not find a significant association between the TNF-308G/A polymorphism and childhood atopic asthma in two independent Japanese populations (P>0.05); however, meta-analysis revealed that the TNF-308G/A polymorphism was statistically significantly associated with asthma. The combined odds ratio with a fixed effects model and with a random effects for TNF-308A was 1.46 (95% confidence interval [CI], 1.27-1.68, P=0.0000001) and 1.46 (95% CI, 1.20-1.77, P=0.00014) respectively. Our data further support the importance of the TNF region in the development of asthma. © The Japan Society of Human Genetics and Springer-Verlag 2006.

引用

页码：677 / 685

页数：8

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