Frailty intervention trial (FIT)

被引：119

作者：

Fairhall N. ^{[1
]}

Aggar C. ^{[2
]}

Kurrle S.E. ^{[3
]}

Sherrington C. ^{[1
]}

Lord S. ^{[4
]}

Lockwood K. ^{[3
]}

Monaghan N. ^{[5
]}

Cameron I.D. ^{[5
]}

机构：

[1] George Institute for International Health, University of Sydney, Sydney, NSW

[2] Faculty of Nursing and Midwifery, University of Sydney, Sydney, NSW

[3] Rehabilitation and Aged Care Services, Hornsby Ku-ring-gai Hospital, Sydney, NSW

[4] Prince of Wales Medical Research Institute, University of New South Wales, Sydney, NSW

[5] Rehabilitation Studies Unit, Faculty of Medicine, University of Sydney, Sydney, NSW

来源：

BMC Geriatrics | / 8卷 / 1期

基金：

英国医学研究理事会;

关键词：

Comprehensive Geriatric Assessment; Short Physical Performance Battery; Frailty Syndrome; Slow Walking Speed; Short Physical Performance Battery Score;

D O I：

10.1186/1471-2318-8-27

中图分类号：

学科分类号：

摘要：

Background. Frailty is a term commonly used to describe the condition of an older person who has chronic health problems, has lost functional abilities and is likely to deteriorate further. However, despite its common use, only a small number of studies have attempted to define the syndrome of frailty and measure its prevalence. The criteria Fried and colleagues used to define the frailty syndrome will be used in this study (i.e. weight loss, fatigue, decreased grip strength, slow gait speed, and low physical activity). Previous studies have shown that clinical outcomes for frail older people can be improved using multi-factorial interventions such as comprehensive geriatric assessment, and single interventions such as exercise programs or nutritional supplementation, but no interventions have been developed to specifically reverse the syndrome of frailty. We have developed a multidisciplinary intervention that specifically targets frailty as defined by Fried et al. We aim to establish the effects of this intervention on frailty, mobility, hospitalisation and institutionalisation in frail older people. Methods and Design. A single centre randomised controlled trial comparing a multidisciplinary intervention with usual care. The intervention will target identified characteristics of frailty, functional limitations, nutritional status, falls risk, psychological issues and management of chronic health conditions. Two hundred and thirty people aged 70 and over who meet the Fried definition of frailty will be recruited from clients of the aged care service of a metropolitan hospital. Participants will be followed for a 12-month period. Discussion. This research is an important step in the examination of specifically targeted frailty interventions. This project will assess whether an intervention specifically targeting frailty can be implemented, and whether it is effective when compared to usual care. If successful, the study will establish a new approach to the treatment of older people at risk of further functional decline and institutionalisation. The strategies to be examined are readily transferable to routine clinical practice and are applicable broadly in the setting of aged care health services. Trial Registration. Australian New Zealand Clinical Trails Registry: ACTRN12608000250336. © 2008 Fairhall et al; licensee BioMed Central Ltd.

引用

共 60 条

[21]

Beswick A., Rees K., Dieppe P., Ayis S., Gooberman-Hill R., Horwood J., Ebrahim S., Complex interventions to improve physical function and maintain independent living in elderly people: A systematic review and meta-analysis, Lancet, 371, pp. 725-735, (2008)

[22]

Gill T.M., Baker D.I., Gottschalk M., Peduzzi P.N., Allore H., Byers A., A program to prevent functional decline in physically frail, elderly persons who live at home, The New England Journal of Medicine, 347, 14, pp. 1068-1074, (2002)

[23]

Fiatarone M.A., O'Neill E.F., Ryan N.D., Clements K.M., Solares G.R., Nelson M.E., Roberts S.B., Kehayias J.J., Lipsitz L.A., Evans W.J., Exercise training and nutritional supplementation for physical frailty in very elderly people, The New England Journal of Medicine, 330, 25, pp. 1769-1775, (1994)

[24]

Page S., Amory J., Bowman F., Anawalt B.D., Matsumoto A.M., Bremner W.J., Tenover J.L., Exogenous testosterone (T) alone or with Finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T, Journal of Clinical Endocrinology Metabolism, 90, pp. 1502-1510, (2005)

[25]

Percheron G., Hogrel J., Denot-Ledunois S., Fayet G., Forette F., Baulieu E.E., Fardeau M., Marini J.F., Effect of a 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross sectional area: A double-blinded placebo-controlled trial, Archives of Internal Medicine, 163, pp. 720-727, (2003)

[26]

Onder G., Penninx B., Balkrishnan R., Fried L., Chaves P., Williamson J., Carter C., Bari M., Guralnik J., Pahor M., Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: An observational study, Lancet, 359, pp. 926-930, (2002)

[27]

Moher D., Schulz K.F., Altman D.G., The CONSORT statement: Revised recommendations for improving the quality of reports of parallel-group randomised trials, Lancet, 357, 9263, pp. 1191-1194, (2001)

[28]

Altman D.G., Schulz K.F., Moher D., Egger M., Davidoff F., Elbourne D., Gotzsche P.C., Lang T., The revised CONSORT statement for reporting randomized trials: Explanation and elaboration, Ann Intern Med, 134, 8, pp. 663-694, (2001)

[29]

Folstein M.F., Folstein S.E., McHugh P.R., Mini-mental state. "a practical method for grading the cognitive state of patients for the clinician, Journal of Psychiatric Research, 12, 3, pp. 189-198, (1975)

[30]

Radloff L.S., The CES-D scale: A self-report depression scale for research in the general population, Applied Psychological Measurement, 1, pp. 385-401, (1977)

← 1 2 3 4 5 6 →