Estrogen receptors: Structure, mechanisms and function

被引：113

作者：

Hewitt S.C. ^{[1
]}

Korach K.S. ^{[1
]}

机构：

[1] Receptor Biology, LRDT, Natl. Inst. of Environ. Hlth. Sci., Research Triangle Park, NC 27709

来源：

Reviews in Endocrine and Metabolic Disorders | 2002年 / 3卷 / 3期

关键词：

Estrogen action; Estrogen receptor; Reproductive tract; Transgenic mice;

D O I：

10.1023/A:1020068224909

中图分类号：

学科分类号：

摘要：

This brief overview has described the well-established mechanisms and physiological functions of ER as well as the frontiers of study that continue to illustrate new details of the mechanisms of action and roles of ER as an important transcriptional modulator. Future investigation promises continuing advances that are eagerly awaited and will have many important applications in diagnostic and therapeutic aspects of reproduction and cancers of reproductive tissues.

引用

页码：193 / 200

页数：7

共 55 条

[21]

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[22]

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[23]

Ignar-Trowbridge D.M., Pimentel M., Parker M.G., McLachlan J.A., Korach K.S., Peptide growth factor cross-talk with the estrogen receptor requires the a/b domain and occurs independently of protein kinase c or estradiol, Endocrinology, 137, pp. 1735-1744, (1996)

[24]

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[25]

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[26]

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[27]

Curtis S.W., Washburn T., Sewall C., DiAugustine R., Lindzey J., Couse J.F., Korach K.S., Physiological coupling of growth factor and steroid receptor signaling pathways: Estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor, Proc Natl Acad Sci USA, 93, pp. 12626-12630, (1996)

[28]

Couse J.F., Korach K.S., Estrogen receptor null mice: What have we learned and where will they lead us?, Endocr Rev, 20, pp. 358-417, (1999)

[29]

Lubahn D.B., Moyer J.S., Golding T.S., Couse J.F., Korach K.S., Smithies O., Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene, Proc Natl Acad Sci USA, 90, pp. 11162-11166, (1993)

[30]

Krege J.H., Hodgin J.B., Couse J.F., Enmark E., Warner M., Mahler J.F., Sar M., Korach K.S., Gustafsson J.A., Smithies O., Generation and reproductive phenotypes of mice lacking estrogen receptor beta, Proc Natl Acad Sci USA, 95, pp. 15677-15682, (1998)

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