A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C

被引：14

作者：

Bayliss M.S. ^{[1
,6
]}

Gandek B. ^{[1
]}

Bungay K.M. ^{[1
]}

Sugano D. ^{[2
]}

Hsu M.-A. ^{[3
]}

Ware Jr. J.E. ^{[1
,4
,5
]}

机构：

[1] Health Institute, New England Medical Center, Boston, MA

[2] Tufts University, School of Medicine

[3] New England Medical Center, Health Institute, Box 345, Boston, MA 02111

来源：

Quality of Life Research | 1997年 / 7卷 / 1期

关键词：

Health status; Hepatitis C; Questionnaire; SF-36 Health Survey;

D O I：

10.1023/A:1008884805251

中图分类号：

学科分类号：

摘要：

A 69-item questionnaire measuring generic functioning and well-being and disease-specific health outcomes was developed and tested using the pre- treatment data from patients with chronic hepatitis C (CHC) participating in two randomized trials of interferon α-2b (n = 157). The questionnaire included all eight scales from the SF-36 and measures of nine other generic and disease-specific health concepts. Psychometric tests confirmed the assumptions underlying the construction and scoring of all generic and disease-specific scales. Cross-sectional tests of 'known groups' validity showed that CHC patients scored worse on the generic scales than patients with other chronic conditions and worse than a healthy general population. The generic and disease-specific scale scores were lower in the presence of physical findings of CHC, as hypothesized, but only the physical functioning and bodily pain scales were linked to cirrhosis or extreme alanine aminotransferase (ALT) ratios. This instrument will be useful in studies of health outcome among patients with CHC, a condition whose health burden appears to have been underestimated in studies to date.

引用

页码：39 / 55

页数：16

共 57 条

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