The development of microbicides for clinical use to prevent sexually transmitted diseases

被引：6

作者：

David M. Phillips

Robin A. Maguire

机构：

[1] The Population Council,

来源：

Current Infectious Disease Reports | 2002年 / 4卷 / 2期

关键词：

Rhesus Macaque; Bacterial Vaginosis; Active Pharmaceutical Ingredient; Sexual Transmission; Candidate Compound;

D O I：

10.1007/s11908-002-0054-7

中图分类号：

学科分类号：

摘要：

Approximately 60 vaginal microbicides are under development for the prevention of HIV/AIDS and other sexually transmitted pathogens. The history and current status of the field are discussed with emphasis on the lessons learned from recent clinical trials, along with an emphasis on the mechanisms involved in the sexual transmission of HIV and how this information influences microbicide development. Additionally, the current status of in vitro and animal systems used for evaluating microbicide efficacy, as well as the challenges involved in developing more appropriate and practical assays, are discussed. Also discussed are the challenges that face the microbicide product development field in meeting US Food and Drug Administration requirements regarding product safety and stability.

引用

页码：135 / 140

页数：5

共 97 条

[11]

Fortney JA(1995)Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques Science 267 1820-1825

[12]

Brown TJ(1993)Studies of adhesion of lymphocytic cells: Implications for sexual transmission of human immunodeficiency virus Biol Reprod 48 431-445

[13]

Yen-Moore A(1993)Productive infection of a cervical epithelial cell line with human immunodeficiency virus: implications for sexual transmission J Virol 67 6447-6452

[14]

Tyring SK(1997)Human immunodeficiency virus type 1 infection of cells and tissues from the upper and lower female reproductive tract J Virol 71 3498-3506

[15]

Percival-Smith R(1997)A role for cell migration in the sexual transmission of HIV Current Biol 7 534-537

[16]

Bartlett KH(1997)Migration of foreign lymphocytes from the mouse vagina into the cervicovaginal mucosa and to the iliac lymph nodes Biol Reprod 56 537-543

[17]

Chow AW(1997)Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier Nat Med 3 42-47

[18]

Niruthisard S(1989)Risk factors for male to female transmission of HIV Br Med J 298 411-415

[19]

Roddy RE(1991)HIV particles detected in spermatozoa of patients with AIDS J Submicr Cytol Pathol 23 339-345

[20]

Chutivongse S(1992)Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques J Med Primatol 21 64-68

← 1 2 3 4 5 6 7 8 9 10 →