The role of anaerobic bacteria in upper respiratory tract and other head and neck infections

被引：25

作者：

Brook I. ^{[1
]}

机构：

[1] Department of Pediatrics, Georgetown University School of Medicine, Washington, DC 20016

来源：

Current Infectious Disease Reports | 2007年 / 9卷 / 3期

关键词：

Cholesteatoma; Tonsillitis; Otitis Medium With Effusion; Chronic Otitis Medium; Chronic Suppurative Otitis Medium;

D O I：

10.1007/s11908-007-0033-0

中图分类号：

学科分类号：

摘要：

Anaerobes are common pathogens in chronic upper respiratory tract and head and neck infections. They can be recovered in chronic otitis media and sinusitis, play a role in tonsillitis, and predominate in complications of these infections, causing deep oral and neck infections and abscesses. In addition to their direct pathogenicity, they play an indirect role through the production of the enzyme β-lactamase, "shielding" non-Β-lactamase-producing bacteria from penicillins. Failure to provide adequate therapy against anaerobes may lead to clinical failures. Management of anaerobic infection is complicated by the slow growth of these organisms, by their polymicrobial nature, and by their growing resistance to antimicrobials. Antimicrobials are often the only form of therapy needed, but surgical approach is needed in some cases. Because anaerobes often are mixed with aerobic organisms, the antimicrobials give should provide adequate coverage against all pathogens. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：208 / 217

页数：9

共 59 条

[11]

Hofstad T., Virulence determinants in non-spore-forming bacteria, Scand J Infect Dis, 62, SUPPL., pp. 15-24, (1989)

[12]

Brook I., The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection, Rev Infect Dis, 6, pp. 601-607, (1984)

[13]

Brook I., Grimm S., Kielich R.B., Bacteriology of acute periapical abscess in children, J Endod, 7, pp. 378-380, (1981)

[14]

Loesche W.J., Syed S.A., Laughon B.E., Stoll J., The bacteriology of acute necrotizing ulcerative gingivitis, J Periodontal, 53, pp. 222-230, (1982)

[15]

Brook I., Anthony B.V., Finegold S.M., Aerobic and anaerobic bacteriology of acute otitis media in children, J Pediatr, 92, pp. 13-15, (1978)

[16]

Brook I., Yocum P., Shah K., Et al., The aerobic and anaerobic bacteriology of serous otitis media, Am J Otolaryngol, 4, pp. 389-392, (1983)

[17]

Brook I., Frazier E.H., Microbial dynamics of persistent purulent otitis media in children, J Pediatr, 128, pp. 237-240, (1996)

[18]

Brook I., Prevalence of beta-lactamase-producing bacteria in chronic suppurative otitis media, AM J Dis Child, 139, pp. 280-284, (1985)

[19]

Sweeney G., Picozzi G.I., Browning G.G., A quantitative study of aerobic and anaerobic bacteria in chronic suppurative otitis media, J Infect, 5, pp. 47-55, (1982)

[20]

Brook I., Aerobic and anaerobic bacteriology of cholesteatoma, Laryngoscope, 91, pp. 250-255, (1981)

← 1 2 3 4 5 6 →