Dietary polyphenols as potential nutraceuticals in management of diabetes: A review

被引：403

作者：

Bahadoran Z. ^{[1
]}

Mirmiran P. ^{[2
]}

Azizi F. ^{[3
]}

机构：

[1] Nutrition and Endocrine Research Center, and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24 Parvaneh St, Yemen St, Chamran Exp, Tehran

[2] Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, No 46 Arghavan-e-gharbi St, Farahzadi Blv, Shahrak

[3] Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No 24 Parvaneh St, Yemen St, Chamran Exp, Tehran

来源：

Journal of Diabetes & Metabolic Disorders | / 12卷 / 1期

关键词：

Diabetes complications; Flavonoids; Lignans; Phenolic acids; Polyphenols; Stilbenes; Type; 2; diabetes;

D O I：

10.1186/2251-6581-12-43

中图分类号：

学科分类号：

摘要：

In recent years, there is growing evidence that plant-foods polyphenols, due to their biological properties, may be unique nutraceuticals and supplementary treatments for various aspects of type 2 diabetes mellitus. In this article we have reviewed the potential efficacies of polyphenols, including phenolic acids, flavonoids, stilbenes, lignans and polymeric lignans, on metabolic disorders and complications induced by diabetes. Based on several in vitro, animal models and some human studies, dietary plant polyphenols and polyphenol-rich products modulate carbohydrate and lipid metabolism, attenuate hyperglycemia, dyslipidemia and insulin resistance, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes. Polyphenolic compounds can also prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy. Further investigations as human clinical studies are needed to obtain the optimum dose and duration of supplementation with polyphenolic compounds in diabetic patients. © 2013 Bahadoran et al.; licensee BioMed Central Ltd.

引用

共 90 条

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