Immune regulation and its role in the pathogenesis of Candida vaginitis

被引：19

作者：

Paul L. Fidel

机构：

[1] Dept. Microbiol. Immunol./Parasitol., Louisiana State University, Health Sciences Center, New Orleans, LA 70112

来源：

Current Infectious Disease Reports | 2003年 / 5卷 / 6期

关键词：

Candidiasis; Vaginitis; Vaginal Mucosa; Killer Toxin; Vaginal Candidiasis;

D O I：

10.1007/s11908-003-0092-9

中图分类号：

学科分类号：

摘要：

The pathogenesis of vulvovaginal candidiasis, which is caused by Candida albicans, is poorly understood. Despite a strong protective role for cell-mediated immunity (CMI) against other mucosal candidal infections, numerous studies in humans and most animal models have revealed little to no role for CMI or other forms of acquired immunity against vaginal candidal infections. Studies suggest that this may be because of immunoregulatory mechanisms that inhibit more profound adaptive immune responses rather than the simple lack of responsiveness. Such regulatory mechanisms significantly influence the pathogenesis of Candida vaginitis. Copyright © 2003 by Current Science Inc.

引用

页码：488 / 493

页数：5

共 49 条

[41] De Bernardis F., Santoni G., Boccanera M., Et al., Local anticandidal immune responses in a rat model of vaginal infection by and protection against Candida albicans, Infect. Immun., 68, pp. 3297-3304, (2000)
[42] Santoni G., Boccanera M., Adriani D., Et al., Immune cell-mediated protection against vaginal candidiasis: Evidence for a major role of vaginal CD4(+) T cells and possible participation of other local lymphocyte effectors, Infect. Immun., 70, pp. 4791-4797, (2002)
[43] Polonelli L., De Bernardis F., Conti S., Et al., Idiotypic intravaginal vaccination to protect against candidal vaginitis by secretory, yeast killer toxin-like anti-idiotypic antibodies, Immunol., 152, pp. 3175-3182, (1994)
[44] De Bernardis F., Boccanera M., Adriana D., Et al., Protective role of antimannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats, Infect. Immun., 65, pp. 3399-3405, (1997)
[45] Deng J.C., Tateda K., Zeng X.Y., Standiford T.J., Transient transgenic expression of gamma interferon promotes Legionella pneumophila clearance in immunocompetent hosts, Infect. Immun., 69, pp. 6382-6390, (2001)
[46] Beninati C., Oggioni M.R., Boccanera M., Et al., Therapy of mucosal candidiasis by expression of an anti-idiotype in human commensal bacteria, Nat. Biotechnol., 18, pp. 1060-1064, (2000)
[47] Magliani W., Conti S., Cassone A., Et al., New immunotherapeutic strategies to control vaginal candidiasis, Trends Mol. Med., 8, pp. 121-126, (2002)
[48] De Bernardis F., Boccanera M., Adriani D., Et al., Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis, Infect. Immun., 70, pp. 2725-2729, (2002)
[49] Cardenas-Freytag L., Steele C., Wormley Jr. F.L., Et al., Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed Candida albicans and the mucosal adjuvant LT(R192G), Med. Mycol., 40, (2001)

← 1 2 3 4 5 →