Complications of androgen-deprivation therapy in men with prostate cancer

被引：23

作者：

Chen A.C. ^{[1
]}

Petrylak D.P. ^{[1
]}

机构：

[1] Department of Medicine, College of Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, MHB 6-435, New York, 10032, NY

来源：

Current Urology Reports | 2005年 / 6卷 / 3期

关键词：

Advanced Prostate Cancer; Androgen Deprivation Therapy; Prostate Cancer; Prostate Cancer Patient; Zoledronic Acid;

D O I：

10.1007/s11934-005-0009-2

中图分类号：

学科分类号：

摘要：

Androgen-deprivation therapy (ADT) is indicated for the treatment of metastatic prostate cancer and locally advanced disease. In addition to sexual side effects, long-term ADT results in several other changes, including hot flashes; gynecomastia; changes in body composition, metabolism, and the cardiovascular system; osteoporosis; anemia; psychiatric and cognitive problems; and fatigue and diminished quality of life. This review discusses these complications of ADT and treatments aimed at reducing them. It is important for clinicians to anticipate these effects and to initiate measures to prevent or minimize them in order to maintain quality of life in prostate cancer survivors. © 2005, Current Science Inc.

引用

页码：210 / 216

页数：6

共 59 条

[11]

Gerber G.S., Zagaja G.P., Ray P.S., Rukstalis D.B., Transdermal estrogen in the treatment of hot flushes in men with prostate cancer, Urology, 55, pp. 97-101, (2000)

[12]

Loprinzi C.L., Michalak J.C., Quella S.K., Et al., Megestrol acetate for the prevention of hot flashes, N Engl J Med, 331, pp. 347-352, (1994)

[13]

Sartor O., Eastham J.A., Progressive prostate cancer associated with use of megestrol acetate administered for control of hot flashes, South Med J, 92, pp. 415-416, (1999)

[14]

Loprinzi C.L., Goldberg R.M., O'Fallon J.R., Et al., Transdermal clonidine for ameliorating post-orchiectomy hot flashes, J Urol, 151, pp. 634-636, (1994)

[15]

Quella S.K., Loprinzi C.L., Sloan J., Et al., Pilot evaluation of venlafaxine for the treatment of hot flashes in men undergoing androgen ablation therapy for prostate cancer, J Urol, 162, pp. 98-102, (1999)

[16]

Roth A.J., Scher H.I., Sertraline relieves hot flashes secondary to medical castration as treatment of advanced prostate cancer, Psychooncology, 7, pp. 129-132, (1998)

[17]

Hammar M., Frisk J., Grimas O., Et al., Acupuncture treatment of vasomotor symptoms in men with prostatic carcinoma: a pilot study, J Urol, 161, pp. 853-856, (1999)

[18]

Spetz A.C., Hammar M., Lindberg B., Et al., Prospective evaluation of hot flashes during treatment with parenteral estrogen or complete androgen ablation for metastatic carcinoma of the prostate, J Urol, 166, pp. 517-520, (2001)

[19]

McLeod D.G., Iversen P., Gynecomastia in patients with prostate cancer: a review of treatment options, Urology, 56, pp. 713-720, (2000)

[20]

Staiman V.R., Lowe F.C., Tamoxifen for flutamide/finasterideinduced gynecomastia, Urology, 50, pp. 929-933, (1997)

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