Improved pharmacological properties for superoxide dismutase modified with β-cyclodextrin–carboxymethylcellulose polymer

被引：4

作者：

Aymara Valdivia

Yunel Pérez

Hector Ramírez

Roberto Cao

Reynaldo Villalonga

机构：

[1] University of Matanzas,Center for Enzyme Technology

[2] Havana University,Faculty of Chemistry, Laboratory of Bioinorganic Chemistry

来源：

Biotechnology Letters | 2006年 / 28卷

关键词：

Anti-inflammatory drug; Carboxymethylcellulose; β-cyclodextrin; Pharmacokinetics; Superoxide dismutase;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Superoxide dismutase was glycosidated with cyclodextrin-branched carboxymethylcellulose. The modified enzyme contained 1.4 mol polymer per mol protein and retained 87% of the initial activity. The anti-inflammatory activity of superoxide dismutase was 2.2-times increased after conjugation and its plasma half-life time was prolonged from 4.8 min to 7.2 h.

引用

页码：1465 / 1470

页数：5

共 65 条

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