Alternatives to immunosuppressive drugs in human islet transplantation.

被引：5

作者：

Cotterell A.A. ^{[1
]}

Kenyon N.S. ^{[1
]}

机构：

[1] Diabetes Research Institute, University of Miami School of Medicine, 1450 N.W. 10th Avenue, Miami, 33136, FL

来源：

Current Diabetes Reports | 2002年 / 2卷 / 4期

关键词：

Islet Transplantation; Tolerance Induction; Allograft Survival; Bone Marrow Trans; Clinical Islet Transplantation;

D O I：

10.1007/s11892-002-0030-5

中图分类号：

学科分类号：

摘要：

Although intensive insulin therapy has resulted in improved metabolic control and decreases in the incidence of complications, the occurrence of severe hypoglycemia remains an issue, as does the continued potential for complications. Islet transplantation, a promising treatment for type I diabetes, has been shown to improve blood sugar levels and decrease or even abrogate the incidence of hypoglycemia. The lack of tissue availability and the toxic effects of immunosuppressants, however, limit the application of islet transplantation as a cure for diabetes. This article discusses possible alternatives to immunosuppressive drugs in human islet transplantations.

引用

页码：377 / 382

页数：5

共 192 条

[21]

Chick WL(1990)Histocompatibility of semi-permeable membranes for implantable diffusion devices (bioartificial pancreas) Transplant Proc 22 834-835

[22]

Like AA(1994)Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation Lancet 343 950-951

[23]

Lauris V(1997)Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets Diabetologia 40 262-270

[24]

Sun AM(1953)Actively acquired tolerance to foreign cells Nature 172 606-606

[25]

Parisius W(1945)Immunogenetic consequences of vascular anastomoses between bovine twins Science 102 400-400

[26]

Healy GM(1993)Control of clonal deletion in the thymus: implications for tolerance induction Immunol Cell Biol 71 337-340

[27]

Archer J(1987)T cell tolerance by clonal elimination in the thymus Cell 49 273-280

[28]

Kaye R(1988)T-cell lineages, repertoire selection and tolerance induction Immunol Rev 104 157-182

[29]

Mutter G(1989)Antiviral T cell competence and restriction specificity of mixed allogeneic (P1 + P2----P1) irradiation chimeras Cell Immunol 121 185-195

[30]

Loudovaris T(1981)Prevention of diabetes in rats by bone marrow transplantation Ann Surg 194 328-338

← 1 2 3 4 5 6 7 8 9 10 →