Energy metabolism in the hypertrophied heart

被引：35

作者：

Sambandam N. ^{[1
,2
]}

Lopaschuk G.D. ^{[2
]}

Brownsey R.W. ^{[3
]}

Allard M.F. ^{[1
]}

机构：

[1] Department of Pathology and Laboratory Medicine, University of British Columbia-St Paul's Hospital, Vancouver

[2] Cardiovascular Research Group, University of Alberta, Edmonton

[3] Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver

来源：

Heart Failure Reviews | 2002年 / 7卷 / 2期

基金：

加拿大健康研究院;

关键词：

Cardiac hypertrophy; Fatty acid oxidation; Glucose oxidation; Glycolysis; Ischemia; Reperfusion;

D O I：

10.1023/A:1015380609464

中图分类号：

学科分类号：

摘要：

In response to a prolonged pressure- or volume-overload, alterations occur in myocardial fatty acid, glucose, and glycogen metabolism. Oxidation of long chain fatty acids has been found to be reduced in hypertrophied hearts compared to non-hypertrophied hearts. However, this observation depends upon the degree of cardiac hypertrophy, the severity of carnitine deficiency, the concentration of fatty acid in blood or perfusate, and the myocardial workload. Glycolysis of exogenous glucose is accelerated in hypertrophied hearts. Despite the acceleration of glycolysis, glucose oxidation is not correspondingly increased leading to lower coupling between glycolysis and glucose oxidation and greater H + production than in non-hypertrophied hearts. Although glycogen metabolism does not differ in the absence of ischemia, synthesis and degradation of glycogen are accelerated in severely ischemic hypertrophied hearts. These alterations in carbohydrate metabolism may contribute to the increased susceptibility of hypertrophied hearts to injury during ischemia and reperfusion by causing disturbances in ion homeostasis that reduce contractile function and efficiency to a greater extent than normal. As in non-hypertrophied hearts, pharmacologic enhancement of coupling between glycolysis and glucose oxidation (e.g., by directly stimulating glucose oxidation) improves recovery of function of hypertrophied hearts after ischemia. This observation provides strong support for the concept that modulation of energy metabolism in the hypertrophied heart is a useful approach to improve function of the hypertrophied heart during ischemia and reperfusion. Future investigations are necessary to determine if alternative approaches, such as glucose-insulin-potassium infusion and inhibitors of fatty acid oxidation (e.g., ranolazine, trimetazidine), also produce beneficial effects in ischemic and reperfused hypertrophied hearts.

引用

页码：161 / 173

页数：12

共 69 条

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