The human gut microbiome: Implications for future health care

被引：96

作者：

Kinross J.M. ^{[1
]}

Roon A.C. ^{[1
]}

Holmes E. ^{[1
]}

Darzi A. ^{[1
]}

Nicholson J.K. ^{[1
]}

机构：

[1] Department of Biomolecular Medicine, Faculty of Medicine, Imperial College, London SW7 2AZ, South Kensington Campus

来源：

Current Gastroenterology Reports | 2008年 / 10卷 / 4期

关键词：

Irritable Bowel Syndrome; Rifaximin; Fecal Microbiota; Human Microbiome Project; Intestinal Microbiome;

D O I：

10.1007/s11894-008-0075-y

中图分类号：

学科分类号：

摘要：

In their intestine, humans possess an "extended genome" of millions of microbial genes-the microbiome. Because this complex symbiosis influences host metabolism, physiology, and gene expression, it has been proposed that humans are complex biologic "superorganisms." Advances in microbiologic analysis and systems biology are now beginning to implicate the gut microbiome in the etiology of localized intestinal diseases such as the irritable bowel syndrome, inflammatory bowel disease, and colon cancer. These approaches also suggest possible links between the gut and previously unassociated systemic conditions such as type 2 diabetes and obesity. The elucidation of the intestinal microbiome is therefore likely to underpin future disease prevention strategies, personalized health care regimens, and the development of novel therapeutic interventions. This review summarizes the research that is defining our understanding of the intestinal microbiome and highlights future areas of research in gastroenterology and human health in which the intestinal microbiome will play a significant role. © Springer Science+Business Media, LLC 2008.

引用

页码：396 / 403

页数：7

共 50 条

[1]

Lederberg J., Infectious history, Science, 288, pp. 287-293, (2000)

[2]

Dethlefsen L., McFall-Ngai M., Relman D.A., An ecological and evolutionary perspective on human-microbe mutualism and disease, Nature, 449, pp. 811-818, (2007)

[3]

Loscalzo J., Kohane I., Barabasi A.L., Human disease classification in the postgenomic era: A complex systems approach to human pathobiology, Mol Syst Biol, 3, (2007)

[4]

Nicholson J.K., Holmes E., Global systems biology and personalized healthcare solutions, Discov Med, 6, pp. 63-70, (2006)

[5]

Nicholson J.K., Holmes E., Wilson I.D., Gut microorganisms, mammalian metabolism and personalized health care, Nat Rev Microbiol, 3, pp. 431-438, (2005)

[6]

Turnbaugh P.J., Ley R.E., Hamady M., Et al., The human microbiome project, Nature, 449, pp. 804-810, (2007)

[7]

Kassinen A., Krogius-Kurikka L., Makivuokko H., Et al., The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects, Gastroenterology, 133, pp. 24-33, (2007)

[8]

Marchesi J.R., Holmes E., Khan F., Et al., Rapid and noninvasive metabonomic characterization of inflammatory bowel disease, J Proteome Res, 6, pp. 546-551, (2007)

[9]

Huycke M.M., Gaskins H.R., Commensal bacteria, redox stress, and colorectal cancer: Mechanisms and models, Exp Biol Med (Maywood), 229, pp. 586-597, (2004)

[10]

Gill S.R., Pop M., Deboy R.T., Et al., Metagenomic analysis of the human distal gut microbiome, Science, 312, pp. 1355-1359, (2006)

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