The human gut microbiome: Implications for future health care

被引：96

作者：

Kinross J.M. ^{[1
]}

Roon A.C. ^{[1
]}

Holmes E. ^{[1
]}

Darzi A. ^{[1
]}

Nicholson J.K. ^{[1
]}

机构：

[1] Department of Biomolecular Medicine, Faculty of Medicine, Imperial College, London SW7 2AZ, South Kensington Campus

来源：

Current Gastroenterology Reports | 2008年 / 10卷 / 4期

关键词：

Irritable Bowel Syndrome; Rifaximin; Fecal Microbiota; Human Microbiome Project; Intestinal Microbiome;

D O I：

10.1007/s11894-008-0075-y

中图分类号：

学科分类号：

摘要：

In their intestine, humans possess an "extended genome" of millions of microbial genes-the microbiome. Because this complex symbiosis influences host metabolism, physiology, and gene expression, it has been proposed that humans are complex biologic "superorganisms." Advances in microbiologic analysis and systems biology are now beginning to implicate the gut microbiome in the etiology of localized intestinal diseases such as the irritable bowel syndrome, inflammatory bowel disease, and colon cancer. These approaches also suggest possible links between the gut and previously unassociated systemic conditions such as type 2 diabetes and obesity. The elucidation of the intestinal microbiome is therefore likely to underpin future disease prevention strategies, personalized health care regimens, and the development of novel therapeutic interventions. This review summarizes the research that is defining our understanding of the intestinal microbiome and highlights future areas of research in gastroenterology and human health in which the intestinal microbiome will play a significant role. © Springer Science+Business Media, LLC 2008.

引用

页码：396 / 403

页数：7

共 50 条

[21]

Strober W., Fuss I., Mannon P., The fundamental basis of inflammatory bowel disease, J Clin Invest, 117, pp. 514-521, (2007)

[22]

Hampe J., Cuthbert A., Croucher P.J., Et al., Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations, Lancet, 357, pp. 1925-1928, (2001)

[23]

Swidsinski A., Ladhoff A., Pernthaler A., Et al., Mucosal flora in inflammatory bowel disease, Gastroenterology, 122, pp. 44-54, (2002)

[24]

Hughes R., Cross A.J., Pollock J.R., Bingham S., Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation, Carcinogenesis, 22, pp. 199-202, (2001)

[25]

Horie H., Kanazawa K., Okada M., Et al., Effects of intestinal bacteria on the development of colonic neoplasm: An experimental study, Eur J Cancer Prev, 8, pp. 237-245, (1999)

[26]

O'Mahony L., Feeney M., O'Halloran S., Et al., Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice, Aliment Pharmacol Ther, 15, pp. 1219-1225, (2001)

[27]

Moore W.E., Moore L.H., Intestinal floras of populations that have a high risk of colon cancer, Appl Environ Microbiol, 61, pp. 3202-3207, (1995)

[28]

Pimentel M., Park S., Mirocha J., Et al., The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: A randomized trial, Ann Intern Med, 145, pp. 557-563, (2006)

[29]

Maukonen J., Satokari R., Matto J., Et al., Prevalence and temporal stability of selected clostridial groups in irritable bowel syndrome in relation to predominant faecal bacteria, J Med Microbiol, 55, pp. 625-633, (2006)

[30]

Spiller R.C., Role of infection in irritable bowel syndrome, J Gastroenterol, 42, SUPPL. 17, pp. 41-47, (2007)

← 1 2 3 4 5 →