共 272 条
[31]
Fisher ER(2001)Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy Pharmacogenomics J 1 65-70
[32]
Rockette HE(2002)Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses J Clin Oncol 20 2832-43
[33]
Fisher B(1999)Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells Int J Oncol 14 551-6
[34]
Wolmark N(1997)Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy Br J Cancer 75 903-9
[35]
Drake JC(1999)A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil Br J Cancer 79 1864-9
[36]
Miyadera K(2001)Discrepancies between the gene expression, protein expression, and enzymatic activity of thymidylate synthase and dihydropyrimidine dehydrogenase in human gastrointestinal cancers and adjacent normal mucosa Int J Oncol 18 705-13
[37]
Sumizawa T(1999)Clinicopathological and prognostic significance of thymidine phosphorylase expression in gastric carcinoma Anticancer Res 19 4363-7
[38]
Haraguchi M(1999)Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice Clin Cancer Res 5 883-9
[39]
Yoshida H(1997)Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy Clin Cancer Res 3 395-9
[40]
Konstanty W(1978)Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil Jpn J Cancer Res 69 763-72